Cumulative exposure to lead in relation to cognitive function in older women.
Cumulative exposure to lead in relation to cognitive function in older women.
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DOI：
10.1289/ehp.11846
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发表时间：
2009-04
影响因子：
10.4
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Weuve J;Korrick SA;Weisskopf MG;Ryan LM;Schwartz J;Nie H;Grodstein F;Hu H
最近的数据表明，长期低水平的铅暴露与老年人认知能力的加速下降有关，但这一点尚未在女性身上进行研究。我们检查了铅暴露的生物标记物与老年女性在一系列认知测试中的表现之间的关系。对587名47-74岁的女性进行了膝盖骨和胫骨铅--多年累积暴露的衡量标准--和血铅--最近暴露的衡量标准--的评估。5年后，我们通过有效的电话采访评估了他们的认知功能。胫骨、膝盖骨和血液中的平均±SD铅水平分别为10.5±9.7μg/g骨、12.6±11.6μg/g骨和2.9±1.9μg/dL，与社区水平的暴露水平一致。在对所有认知测试组合进行的多变量调整分析中，所有三个主要生物标志物的水平都与较差的认知表现有关。骨铅和字母流畅性分数之间的关联与其他骨铅-认知分数之间的关联有很大不同，从联合分析中排除这一特定分数加强了骨铅和认知表现之间的关联。结果仅对胫骨铅有统计学意义：胫骨铅每增加一个SD对应的标准化综合认知分数降低0.051个单位(95%可信区间：−0.099至−0.003；p=0.04)，与我们观察到的年龄相差3岁的女性之间的认知分数差异相似。这些发现表明，累积接触铅，即使是在社区环境中经历的低水平，也可能对老年女性的认知产生不利影响。
Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. We examined biomarkers of lead exposure in relation to performance on a battery of cognitive tests among older women. Patella and tibia bone lead—measures of cumulative exposure over many years—and blood lead, a measure of recent exposure, were assessed in 587 women 47–74 years of age. We assessed their cognitive function 5 years later using validated telephone interviews. Mean ± SD lead levels in tibia, patella, and blood were 10.5 ± 9.7 μg/g bone, 12.6 ± 11.6 μg/g bone, and 2.9 ± 1.9 μg/dL, respectively, consistent with community-level exposures. In multivariable-adjusted analyses of all cognitive tests combined, levels of all three lead biomarkers were associated with worse cognitive performance. The association between bone lead and letter fluency score differed dramatically from the other bone lead-cognitive score associations, and exclusion of this particular score from the combined analyses strengthened the associations between bone lead and cognitive performance. Results were statistically significant only for tibia lead: one SD increase in tibia lead corresponded to a 0.051-unit lower standardized summary cognitive score (95% confidence interval: −0.099 to −0.003; p = 0.04), similar to the difference in cognitive scores we observed between women who were 3 years apart in age. These findings suggest that cumulative exposure to lead, even at low levels experienced in community settings, may have adverse consequences for women’s cognition in older age.
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影响因子：
7.4
作者：
Ercal, N;Treeratphan, P;Spitz, DR
通讯作者：
Spitz, DR
影响因子：
4.8
作者：
He, LH;Poblenz, AT;Fox, DA
通讯作者：
Fox, DA
DOI：
10.1111/j.1532-5415.2004.52407.x
发表时间：
2004-09-01
影响因子：
6.3
作者：
Chodosh, J;Seeman, TE;Reuben, DB
通讯作者：
Reuben, DB
影响因子：
4.5
作者：
Adonaylo, VN;Oteiza, PI
通讯作者：
Oteiza, PI
影响因子：
168.9
作者：
Ferri, CP;Prince, M;Scazufca, M
通讯作者：
Scazufca, M