The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy.
The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy.
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DOI：
10.3389/fimmu.2023.1154566
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在过去的几十年里，使用过继细胞疗法治疗癌症的进展使复发/难治性或晚期恶性肿瘤患者获得了前所未有的疗效。然而，细胞衰竭和衰老限制了fda批准的t细胞疗法在血液恶性肿瘤患者中的疗效，以及该方法在治疗实体瘤患者中的广泛应用。研究人员正在通过关注效应T细胞的制造过程来解决当前的障碍，包括工程方法和体外扩增策略来调节T细胞分化。在这里，我们回顾了目前在体外制造过程中增强t细胞扩增、持久性和功能的小分子策略。我们进一步讨论了双靶向方法的协同效益，并提出了新型血管活性肠肽受体拮抗剂（VIPR-ANT）肽作为增强细胞免疫治疗的新兴候选药物。
In the past decades, advances in the use of adoptive cellular therapy to treat cancer have led to unprecedented responses in patients with relapsed/refractory or late-stage malignancies. However, cellular exhaustion and senescence limit the efficacy of FDA-approved T-cell therapies in patients with hematologic malignancies and the widespread application of this approach in treating patients with solid tumors. Investigators are addressing the current obstacles by focusing on the manufacturing process of effector T cells, including engineering approaches and ex vivo expansion strategies to regulate T-cell differentiation. Here we reviewed the current small-molecule strategies to enhance T-cell expansion, persistence, and functionality during ex vivo manufacturing. We further discussed the synergistic benefits of the dual-targeting approaches and proposed novel vasoactive intestinal peptide receptor antagonists (VIPR-ANT) peptides as emerging candidates to enhance cell-based immunotherapy.
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影响因子：
7.4
作者：
Davis JE;Sharpe C;Mason K;Tam CS;Koldej RM;Ritchie DS
通讯作者：
Ritchie DS
影响因子：
64.8
作者：
De Henau O;Rausch M;Winkler D;Campesato LF;Liu C;Cymerman DH;Budhu S;Ghosh A;Pink M;Tchaicha J;Douglas M;Tibbitts T;Sharma S;Proctor J;Kosmider N;White K;Stern H;Soglia J;Adams J;Palombella VJ;McGovern K;Kutok JL;Wolchok JD;Merghoub T
通讯作者：
Merghoub T
影响因子：
64.8
作者：
Ali K;Soond DR;Pineiro R;Hagemann T;Pearce W;Lim EL;Bouabe H;Scudamore CL;Hancox T;Maecker H;Friedman L;Turner M;Okkenhaug K;Vanhaesebroeck B
通讯作者：
Vanhaesebroeck B
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
影响因子：
7.3
作者：
Chandrasekaran S;Funk CR;Kleber T;Paulos CM;Shanmugam M;Waller EK
通讯作者：
Waller EK