Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy.
Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy.
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DOI：
10.1155/2012/740381
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发表时间：
2012
影响因子：
2
通讯作者：
Gasbarrini A
中科院分区：
文献类型：
--
作者：
Ojetti V;Bruno G;Ainora ME;Gigante G;Rizzo G;Roccarina D;Gasbarrini A
导言。根除幽门螺杆菌治疗有潜在的抗生素相关性胃肠道(GI)副作用。副作用的发生是此类方案的主要缺点之一。胃肠道感染的表现可能与肠道菌群改变有关。益生菌可以预防或减少抗生素相关的副作用，并对幽门螺杆菌有抑制作用。方法：研究方法。确定补充reuri乳杆菌在根除幽门螺杆菌和预防左氧氟沙星三联二线治疗期间胃肠道相关副作用方面的有效性。90例幽门螺杆菌阳性患者接受埃索美拉唑、左氧氟沙星、阿莫西林与路支杆菌联合二线三联治疗7天(组1)和未服用益生菌的患者(组2)。每个受试者都接受了一份有效的问卷，从治疗开始的4周内每天记录症状。治疗6周后评估幽门螺杆菌感染状况和不良反应。结果。添加罗氏乳杆菌益生菌对根治率有显著影响(第1组：36/45，80%；第2组：28/45，62%；P<；0.05)。第1组恶心、腹泻发生率明显低于第2组。在幽门螺杆菌阳性的受试者中，补充L.reuri可提高根治率，同时减少二线治疗中与抗生素治疗相关的最常见副作用的发生率。
Introduction. Helicobacter pylori eradication therapy has the potential burden of antibiotic-associated gastrointestinal (GI) side effects. The occurrence of side effects is among the major drawbacks of such regimens. GI manifestations may be related to alterations in the intestinal microflora. Probiotics can prevent or reduce antibiotic-associated side effects and have an inhibitory effect on H. pylori. Methods. To define the efficacy of Lactobacillus reuteri supplementation in H. pylori eradication and in preventing GI-associated side effects during a second-line levofloxacin triple therapy. 90 H. pylori-positive patients receive for 7 days a second-line triple therapy with esomeprazole, levofloxacin, and amoxicillin with L. reuteri for 14 days (group 1) and without probiotic supplementation (group 2). Each subject received a validated questionnaire to record symptoms everyday for 4 weeks from the start of therapy. H. pylori status and side effects were assessed 6 weeks after treatment. Results. The eradication rate was significantly influenced by probiotic supplementation with L. reuteri (group 1: 36/45, 80%; group 2: 28/45 62%; P < 0.05). The incidence of nausea and diarrhoea in group 1 was significantly lower than that in group 2. Conclusion. In H. pylori-positive subjects L. reuteri supplementation increases the eradication rate while reducing the incidence of the most common side effects associated with antibiotic therapy in second-line treatment.
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影响因子：
3.7
作者：
Graham, DY;Klein, PD
通讯作者：
Klein, PD
影响因子：
4.4
作者：
Francavilla, Ruggiero;Lionetti, Elena;Miniello, Vito Leonardo
通讯作者：
Miniello, Vito Leonardo
影响因子：
7
作者：
Hedin, Charlotte;Whelani, Kevin;Lindsay, James O.
通讯作者：
Lindsay, James O.
影响因子：
4.4
作者：
Goldman, Cinthia G.;Barrado, Domingo A.;Boccio, Jose R.
通讯作者：
Boccio, Jose R.
影响因子：
5.2
作者：
Adamsson, I;Nord, CE;Edlund, C
通讯作者：
Edlund, C