Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model
Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model
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异性接触与隔离：一种新的抑郁/焦虑模型
DOI：
10.1007/s12264-015-0002-9
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发表时间：
2016-01
影响因子：
5.6
通讯作者：
Yu-Qiu Zhang
中科院分区：
文献类型：
--
作者：
Qiu-Qin Han;Jin Yu;Gen-Cheng Wu;Yu-Qiu Zhang
为了模仿人类情绪障碍，传统的慢性压力和社会失败压力已经被开发并广泛应用。然而，这些主动压力并不模仿压力引起的情绪缺陷，而且它们的输入水平差异很大。此外，由于缺乏有用的动物模型，由于社交无法获得而导致的情绪压力在很大程度上仍然难以捉摸。在这项研究中，我们开发了一种名为“异性接触和隔离”（OSCI）的小鼠模型，发现 OSCI 会诱发显着的社交回避、快感缺乏和焦虑。经过 7 天的 OSCI 后，这些行为缺陷的发展有所不同。社交回避行为是可以自我治愈的，而焦虑则逐渐恶化，但通过与同一女性伴侣重新配对而缓解。与行为变化相对应的是，经历隔离的小鼠伏核中血浆皮质酮和磷酸化cAMP反应元件结合蛋白水平降低。总之，这项研究开发了一种抑郁/焦虑建模的新策略，并表明 OSCI 可能是研究失恋/病相思型抑郁症的有用工具。
To mimic human mood disorders, traditional chronic stresses and social defeat stress have been developed and widely applied. However, these active stresses do not mimic the emotional flaws induced by stresses, and their input levels vary greatly. Also, emotional stresses resulting from social unobtainability remain largely elusive due to the lack of useful animal models. In this study, we developed a mouse model named “opposite sex contact and isolation” (OSCI) and found that OSCI induced significant social avoidance, anhedonia, and anxiety. These behavioral defects developed differently after 7 days of OSCI. The social avoidance behavior was self-curable while anxiety gradually worsened but was alleviated by re-pairing with the same female partner. Corresponding to the behavior changes, the plasma corticosterone and phosphorylated cAMP response element binding protein levels were decreased in the nucleus accumbens of the mice that experienced isolation. Together, this study has developed a novel strategy for depression/anxiety modeling and shows that OSCI may be a useful tool for studying the lovelorn/lovesick type of depression.
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