Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer analysis of human tumors.
Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer analysis of human tumors.
复制标题
DOI：
10.1080/21655979.2021.1940042
复制
发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Li Z;Hu N;Dai L;Hou X;Hu W;Liang W;Wang X
有一些证据支持Cullin-5（CUL 5）与癌症之间的关联，但以前没有进行过使用泛癌症分析的研究。因此，我们研究了CUL 5在基因表达Omnibus和癌症基因组图谱数据库中的33种肿瘤中的致癌作用。许多癌症降低CUL 5水平，某些癌症的预后与CUL 5表达密切相关。CUL 5表达与葡萄膜黑色素瘤和头颈部鳞状细胞癌中的CD 8 + T细胞浸润水平相关，我们观察到CUL 5与Tcm（T中枢记忆）细胞之间呈正相关，而T辅助（Th）细胞与pDC（浆细胞样DC）之间呈负相关。CUL 5与NK细胞、NK CD 56 bright细胞、NK CD 56 dim细胞、T细胞、细胞毒性细胞和Th 17细胞呈负相关。与蛋白质加工和泛素相关的功能包括在CUL 5功能机制中。筛选出与CUL 5相关性最强的前100个基因，富集分析表明与CUL 5相关性最强的生物学过程为neddylation，相关通路包括TGF-β信号通路和胞内受体信号通路。CUL 5与染色体分离和染色体组构的正调控等生物细胞行为有关。作为第一个对CUL 5进行泛癌症分析的研究，本研究结果将提高对CUL 5在不同肿瘤中致癌作用的理解。
There is some evidence supporting an association between Cullin-5 (CUL5) and cancer, but no research using pan-cancer analysis has been conducted previously. We therefore investigated the oncogenic role of CUL5 in 33 tumors from the Gene Expression Omnibus and The Cancer Genome Atlas databases. Many cancers reduce CUL5 levels, and the prognosis of certain cancers is vitally linked with CUL5 expression. CUL5 expression is associated with CD8 + T-cell infiltration levels in uveal melanomas and head and neck squamous cell carcinomas, and we observed a positive relationship between CUL5 and Tcm (T central memory) cells, and a negative relationship between T helper (Th) cells and pDC (plasmacytoid DC). CUL5 had negative associations with NK cells, NK CD56bright cells, NK CD56dim cells, Tregs, cytotoxic cells, and Th17 cells. Functions relating to protein processing and ubiquitin were included in the CUL5 functional mechanisms. The top 100 genes that are most strongly related to CUL5 were identified, and enrichment analysis indicated that the biological process with the closest relationship was neddylation, related pathways included the TGF-beta signaling pathway and intracellular receptor signaling pathway. CUL5 is related to biological cell behaviors such as chromosome segregation and positive regulation of chromosome organization. As the first study to perform a pan-cancer analysis of CUL5, the present findings will improve the understanding of the oncogenic role of CUL5 in different tumors.
登录
查看更多内容
DOI：
10.1056/nejmoa1914919
发表时间：
2020-05-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lee YR;Yehia L;Kishikawa T;Ni Y;Leach B;Zhang J;Panch N;Liu J;Wei W;Eng C;Pandolfi PP
通讯作者：
Pandolfi PP
DOI：
10.1007/978-981-15-1025-0_6
发表时间：
2020-01-01
期刊：
CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS
影响因子：
--
作者：
Fu, Lin;Cui, Chun-Ping;Zhang, Lingqiang
通讯作者：
Zhang, Lingqiang
影响因子：
3.9
作者：
Si, Lihui;Jia, Yan;Yang, Shuli
通讯作者：
Yang, Shuli
影响因子：
4.2
作者：
Devor EJ;Schickling BM;Reyes HD;Warrier A;Lindsay B;Goodheart MJ;Santillan DA;Leslie KK
通讯作者：
Leslie KK
影响因子：
5.6
作者：
Blondelle J;Biju A;Lange S
通讯作者：
Lange S