Control selection and pesticide exposure assessment via GIS in prostate cancer studies.
Control selection and pesticide exposure assessment via GIS in prostate cancer studies.
复制标题
在前列腺癌研究中通过 GIS 进行控制选择和农药暴露评估。
DOI：
10.1016/j.amepre.2005.09.002
复制
发表时间：
2006
影响因子：
5.5
通讯作者：
Ritz,BeateR
中科院分区：
文献类型：
--
作者：
Marusek,JenniferC;Cockburn,MylesG;Mills,PaulK;Ritz,BeateR
农药暴露最近与前列腺癌有关，但迄今为止准确的暴露评估一直具有挑战性。此外，很少对历史暴露进行审查。评估住宅暴露于农药的地理信息系统（GIS）为基础的模型的效用是在一个以人口为基础的病例对照设置之间的组容易招募为对照subjects.METHODS历史农药和土地使用数据被用来生成暴露措施，以前与前列腺癌的风险控制系列和前列腺癌病例在三个农村加州县的两个不同的农药。简单估计的住宅接触不同的接触期之间的情况下，对照组和完整的居住历史的价值进行了比较examined.OXTS住宅接触甲基溴的基础上，目前的地址导致在一个高估的接触遥远的接触期，而接触有机氯是类似的，无论历史的居住信息。在医疗保险控制，未暴露的老年人对照组的特点是由一个较高的response rate.CONCLUSIONSSThe频率和农药的应用量似乎影响引入到基于GIS的暴露评估的偏见的响应偏差检测。将受试者的完整居住史纳入暴露估计值的计算似乎可以减少来自该来源的偏倚，但也可能通过对照自我选择引入额外的偏倚。使用随机抽样控制从医疗保险和住宅包裹列表独立的主题响应似乎导致农药暴露的相对公正的估计的机会。
BACKGROUNDPesticide exposures have recently been linked to prostate cancer, but accurate exposure assessment to date has been challenging. Additionally, historical exposures have rarely been examined. The utility of a geographic information system (GIS)–based model for assessing residential exposure to pesticides is examined in a population-based case–control setting among groups easily recruited as control subjects.METHODSHistorical pesticide and land-use data were used to generate exposure measures for two distinct pesticides previously linked to prostate cancer risk for control series and prostate cancer cases in three rural California counties. Simple estimates of residential exposures for different exposure periods are compared between case and control groups and the value of complete residential histories is examined.RESULTSResidential exposure to methyl bromide based on current address resulted in an overestimation of exposure for distant exposure periods, whereas exposures to organochlorines were similar regardless of availability of historical residence information. A response bias was detected in Medicare controls such that unexposed elderly control subjects were characterized by a higher response rate.CONCLUSIONSThe frequency and amount of application of pesticides seem to affect the bias introduced into GIS-based exposure assessments. Inclusion of subjects’ complete residential histories into the computation of exposure estimates seems to reduce bias from this source, but it may also introduce an additional bias through control self-selection. The use of randomly sampled controls from Medicare and residential parcels listings independent of subject response seems to result in the opportunity for relatively unbiased estimates of pesticide exposures.
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空中和地面施用的农药漂移。
DOI：
--
发表时间：
1970
期刊：
影响因子：
--
作者：
K. R. Frost;G. Ware
通讯作者：
G. Ware
影响因子：
2.2
作者：
CURRIER, WW;MACCOLLOM, GB;BAUMANN, GL
通讯作者：
BAUMANN, GL
影响因子：
2.2
作者：
MACCOLLOM, GB;CURRIER, WW;BAUMANN, GL
通讯作者：
BAUMANN, GL
影响因子：
3.5
作者：
Mills, PK;Kwong, S
通讯作者：
Kwong, S
土地利用调查
DOI：
--
发表时间：
1975
期刊：
影响因子：
--
作者：
A. Vink
通讯作者：
A. Vink