Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice.
Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice.
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肠道微生物群组成异常导致 SAMP8 小鼠认知功能障碍
DOI：
10.18632/aging.101464
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发表时间：
2018-06-10
期刊：
影响因子：
--
通讯作者：
Luo A
中科院分区：
文献类型：
--
作者：
Zhan G;Yang N;Li S;Huang N;Fang X;Zhang J;Zhu B;Yang L;Yang C;Luo A
阿尔茨海默病以认知功能障碍为特征，衰老是重要的易感因素；然而，病理和治疗机制尚不完全清楚。近年来，肠道菌群在阿尔茨海默病中的作用越来越受到关注。与衰老加速小鼠抗衰老1 （SAMR1）相比，SAMP8小鼠的认知功能明显下降，Chao 1和Shannon指数、主坐标分析、主成分分析结果均明显异常。此外，在SAMP8和SAMR1小鼠之间，27种肠道细菌在6个系统发育水平上存在差异。在另一项研究中，我们将SAMP8或SAMR1小鼠的粪便细菌移植到伪无菌小鼠中。有趣的是，假无菌小鼠在移植前的认知功能明显降低。接受SAMR1小鼠粪菌移植而非SAMP8小鼠粪菌移植的伪无菌小鼠的行为以及α-多样性和β-多样性指数均有所改善。总共有14种细菌在6个系统发育水平上被肠道菌群移植显著改变。这些结果表明，SAMP8小鼠的认知功能障碍与肠道微生物群的异常组成有关。因此，改善异常肠道菌群可能为认知功能障碍和阿尔茨海默病提供另一种治疗方法。
Alzheimer’s disease is characterized by cognitive dysfunction and aging is an important predisposing factor; however, the pathological and therapeutic mechanisms are not fully understood. Recently, the role of gut microbiota in Alzheimer’s disease has received increasing attention. The cognitive function in senescence-accelerated mouse prone 8 (SAMP8) mice was significantly decreased and the Chao 1 and Shannon indices, principal coordinates analysis, and principal component analysis results were notably abnormal compared with that of those in senescence-accelerated mouse resistant 1 (SAMR1) mice. Moreover, 27 gut bacteria at six phylogenetic levels differed between SAMP8 and SAMR1 mice. In a separate study, we transplanted fecal bacteria from SAMP8 or SAMR1 mice into pseudo germ-free mice. Interestingly, the pseudo germ-free mice had significantly lower cognitive function prior to transplant. Pseudo germ-free mice that received fecal bacteria transplants from SAMR1 mice but not from SAMP8 mice showed improvements in behavior and in α-diversity and β-diversity indices. In total, 14 bacteria at six phylogenetic levels were significantly altered by the gut microbiota transplant. These results suggest that cognitive dysfunction in SAMP8 mice is associated with abnormal composition of the gut microbiota. Thus, improving abnormal gut microbiota may provide an alternative treatment for cognitive dysfunction and Alzheimer’s disease.
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影响因子：
4.8
作者：
Leblhuber F;Egger M;Schuetz B;Fuchs D
通讯作者：
Fuchs D
DOI：
10.18632/aging.100838
发表时间：
2015-11
期刊：
Aging
影响因子：
--
作者：
Currais A;Goldberg J;Farrokhi C;Chang M;Prior M;Dargusch R;Daugherty D;Armando A;Quehenberger O;Maher P;Schubert D
通讯作者：
Schubert D
DOI：
10.1007/s13311-017-0600-5
发表时间：
2018-01
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Farzi A;Fröhlich EE;Holzer P
通讯作者：
Holzer P
影响因子：
4.6
作者：
Harach T;Marungruang N;Duthilleul N;Cheatham V;Mc Coy KD;Frisoni G;Neher JJ;Fåk F;Jucker M;Lasser T;Bolmont T
通讯作者：
Bolmont T
DOI：
10.18632/aging.101333
发表时间：
2017-12-01
期刊：
Aging
影响因子：
--
作者：
Harris SE;Riggio V;Evenden L;Gilchrist T;McCafferty S;Murphy L;Wrobel N;Taylor AM;Corley J;Pattie A;Cox SR;Martin-Ruiz C;Prendergast J;Starr JM;Marioni RE;Deary IJ
通讯作者：
Deary IJ