Shift work is associated with positive COVID-19 status in hospitalised patients.
Shift work is associated with positive COVID-19 status in hospitalised patients.
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DOI：
10.1136/thoraxjnl-2020-216651
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发表时间：
2021-06
期刊：
影响因子：
10
通讯作者：
Blaikley JF
中科院分区：
文献类型：
--
作者：
Maidstone R;Anderson SG;Ray DW;Rutter MK;Durrington HJ;Blaikley JF
轮班工作与肺部疾病和感染有关。因此，我们调查了轮班工作对重大 COVID-19 疾病的影响。 501 000 名英国生物银行参与者与英格兰公共卫生部门的二级护理 SARS-CoV-2 PCR 结果相关联。医护人员职业测试和没有职业史的人员被排除在分析之外。多变量逻辑回归（年龄、性别、种族和剥夺指数）显示，不规则轮班工作（OR 2.42，95% CI 1.92至3.05）、长期轮班工作（OR 2.5，95% CI 1.95至3.19）、白班工作（OR 2.01，95% CI 1.55至2.6）、不规则夜班与不进行轮班工作的参与者相比，长期工作（OR 3.04，95%CI 2.37 至 3.9）和永久性夜班工作（OR 2.49，95%CI 1.67 至 3.7）均与 COVID-19 检测呈阳性相关。在模型中添加睡眠时间、睡眠时间型、病前疾病、体重指数、酒精和吸烟后，这种关系仍然存在。工作场所的影响通过三种方式进行控制：(1) 在多变量模型中添加工作因素（与同事的接近程度以及估计的疾病暴露程度），或 (2) 比较每个工作部门（非必需品、必需品和医疗保健）内的参与者，以及 (3) 比较轮班工作和非轮班工作的同事。在所有情况下，轮班工作都与 COVID-19 显着相关。 2017 年，120-307 名英国生物银行参与者的职业史被重新描述。使用此更新的职业数据，轮班工作仍然与 COVID-19 相关（OR 4.48（95% CI 1.8 至 11.18）。轮班工作与院内 COVID-19 阳性的可能性较高有关。通过额外的工作场所预防措施或疫苗接种可能会减轻这种风险。
Shift work is associated with lung disease and infections. We therefore investigated the impact of shift work on significant COVID-19 illness. 501 000 UK Biobank participants were linked to secondary care SARS-CoV-2 PCR results from Public Health England. Healthcare worker occupational testing and those without an occupational history were excluded from analysis. Multivariate logistic regression (age, sex, ethnicity and deprivation index) revealed that irregular shift work (OR 2.42, 95% CI 1.92 to 3.05), permanent shift work (OR 2.5, 95% CI 1.95 to 3.19), day shift work (OR 2.01, 95% CI 1.55 to 2.6), irregular night shift work (OR 3.04, 95% CI 2.37 to 3.9) and permanent night shift work (OR 2.49, 95% CI 1.67 to 3.7) were all associated with positive COVID-19 tests compared with participants that did not perform shift work. This relationship persisted after adding sleep duration, chronotype, premorbid disease, body mass index, alcohol and smoking to the model. The effects of workplace were controlled for in three ways: (1) by adding in work factors (proximity to a colleague combined with estimated disease exposure) to the multivariate model or (2) comparing participants within each job sector (non-essential, essential and healthcare) and (3) comparing shift work and non-shift working colleagues. In all cases, shift work was significantly associated with COVID-19. In 2017, 120 307 UK Biobank participants had their occupational history reprofiled. Using this updated occupational data shift work remained associated with COVID-19 (OR 4.48 (95% CI 1.8 to 11.18). Shift work is associated with a higher likelihood of in-hospital COVID-19 positivity. This risk could potentially be mitigated via additional workplace precautions or vaccination.
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影响因子：
16.2
作者：
Vetter C;Dashti HS;Lane JM;Anderson SG;Schernhammer ES;Rutter MK;Saxena R;Scheer FAJL
通讯作者：
Scheer FAJL
DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
3.5
作者：
Juda, Myriam;Vetter, Celine;Roenneberg, Till
通讯作者：
Roenneberg, Till
影响因子：
24.3
作者：
De Matteis, Sara;Jarvis, Deborah;Cullinan, Paul
通讯作者：
Cullinan, Paul
影响因子：
33.9
作者：
Dyal, Jonathan W.;Grant, Michael P.;Honein, Margaret A.
通讯作者：
Honein, Margaret A.