Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.
Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.
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DOI：
10.2337/dc17-1933
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发表时间：
2018-04
期刊：
影响因子：
16.2
通讯作者：
Scheer FAJL
中科院分区：
文献类型：
--
作者：
Vetter C;Dashti HS;Lane JM;Anderson SG;Schernhammer ES;Rutter MK;Saxena R;Scheer FAJL
研究过去和现在的夜班工作和遗传2型糖尿病易感性对2型糖尿病发病率的影响。在英国生物库中，我们检查了当前（N = 272，214）和终身（N = 70，480）夜班工作暴露与2型糖尿病风险的相关性（分别为6，770和1，191例流行病例）。对于180，704和44，141名具有遗传数据的欧洲血统的无关参与者（分别为4，002和726例），我们评估了轮班工作暴露是否改变了2型糖尿病遗传风险评分（包括110个单核苷酸多态性）与糖尿病患病率之间的关系。与白班工人相比，目前所有夜班工人患2型糖尿病的多变量调整几率更高（无夜班或很少夜班：比值比[OR] 1.15 [95% CI 1.05-1.26];某些夜班：OR 1.18 [95% CI 1.05-1.32];以及普通夜班：OR 1.44 [95% CI 1.19-1.73]），当前长期夜班工人除外（OR 1.09 [95% CI 0.93-1.27]）。考虑到一个人一生的工作时间表，与从不轮班的工人相比，每月上更多夜班与更高的2型糖尿病几率相关（<3/月：OR 1.24 [95% CI 0.90-1.68]; 3-8/月：OR 1.11 [95% CI 0.90-1.37];和>8/月：OR 1.36 [95% CI 1.14-1.62]; P趋势= 0.001）。遗传性2型糖尿病易感性和2型糖尿病发病率之间的关联并没有被轮班工作暴露所改变。我们的研究结果表明，夜班工作，特别是包括夜班在内的轮班工作，与2型糖尿病的发病率较高有关，每月夜班工作的次数似乎与2型糖尿病的发病率最相关。此外，轮班工作暴露不会改变2型糖尿病的遗传风险，这是一项值得复制的新发现。
To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds. In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 and 1,191 prevalent cases, respectively). For 180,704 and 44,141 unrelated participants of European ancestry (4,002 and 726 cases, respectively) with genetic data, we assessed whether shift work exposure modified the relationship between a genetic risk score (comprising 110 single-nucleotide polymorphisms) for type 2 diabetes and prevalent diabetes. Compared with day workers, all current night shift workers were at higher multivariable-adjusted odds for type 2 diabetes (none or rare night shifts: odds ratio [OR] 1.15 [95% CI 1.05–1.26]; some nights: OR 1.18 [95% CI 1.05–1.32]; and usual nights: OR 1.44 [95% CI 1.19–1.73]), except current permanent night shift workers (OR 1.09 [95% CI 0.93–1.27]). Considering a person’s lifetime work schedule and compared with never shift workers, working more night shifts per month was associated with higher type 2 diabetes odds (<3/month: OR 1.24 [95% CI 0.90–1.68]; 3–8/month: OR 1.11 [95% CI 0.90–1.37]; and >8/month: OR 1.36 [95% CI 1.14–1.62]; Ptrend = 0.001). The association between genetic type 2 diabetes predisposition and type 2 diabetes odds was not modified by shift work exposure. Our findings show that night shift work, especially rotating shift work including night shifts, is associated with higher type 2 diabetes odds and that the number of night shifts worked per month appears most relevant for type 2 diabetes odds. Also, shift work exposure does not modify genetic risk for type 2 diabetes, a novel finding that warrants replication.
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DOI：
10.1056/nejmoa1605086
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
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作者：
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10.3109/09540261.2014.911149
发表时间：
2014-04
期刊：
International review of psychiatry (Abingdon, England)
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