Determinants of serum enterolactone concentration.
Determinants of serum enterolactone concentration.
复制标题
血清肠内酯浓度的决定因素。
DOI：
10.1093/ajcn/73.6.1094
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
H. Adlercreutz
中科院分区：
文献类型：
--
作者：
A. Kilkkinen;K. Stumpf;P. Pietinen;L. Valsta;H. Tapanainen;H. Adlercreutz
背景
木脂素肠内酯，这是由肠道微生物菌群从饮食前体产生的，可以防止依赖性癌症和心血管疾病。
目的
我们研究了芬兰成年人血清肠内酯浓度与饮食和健康相关变量之间的横断面相关性。
设计
采用时间分辨荧光免疫分析法测定了2380名年龄在25-64岁之间的芬兰男性和女性的血清肠内酯水平，这些男性和女性参加了1997年的全国横断面调查。背景信息通过自填问卷收集，饮食通过食物频率问卷评估。
结果
男性中位血清肠内酯浓度为13.8 nmol/L（范围：0-95.6 nmol/L），女性中位血清肠内酯浓度为16.6 nmol/L（范围：0-182.6 nmol/L）。多元回归分析显示，男性血清肠内酯浓度与便秘、全麦产品消费量、水果和浆果摄入量呈正相关。在女性中，血清肠内酯浓度与蔬菜摄入量、受试者年龄和便秘呈正相关，与吸烟呈负相关。此外，体重正常的女性受试者血清肠内酯浓度明显高于体重不足或肥胖的同龄人。
结论
血清肠内酯浓度在人群中变化很大。在我们研究的变量中，血清肠内酯浓度的最重要决定因素是食用含木脂素的食物和便秘;然而，这些似乎只能解释一小部分的变化。因此，肠道菌群在木脂素代谢中的作用可能非常重要。还需要进一步的研究来确定木脂素的生物利用度和吸收率。
BACKGROUND
The lignan enterolactone, which is produced by the intestinal microflora from dietary precursors, may protect against hormone-dependent cancers and cardiovascular diseases.
OBJECTIVE
We examined the cross-sectional associations between the serum enterolactone concentration and variables related to diet and health in Finnish adults.
DESIGN
Serum enterolactone was measured by using time-resolved fluoroimmunoassay in 2380 Finnish men and women aged 25-64 y who were participating in a cross-sectional national survey in 1997. Background information was collected with self-administered questionnaires and the diet was assessed with a food-frequency questionnaire.
RESULTS
The median serum enterolactone concentration was 13.8 nmol/L (range: 0-95.6 nmol/L) in men and 16.6 nmol/L (range: 0-182.6 nmol/L) in women. Multiple regression analyses showed positive associations in men between the serum enterolactone concentration and constipation, consumption of whole-grain products, and intake of fruit and berries. In women, the serum enterolactone concentration was positively and independently associated with consumption of vegetables, subject age, and constipation and was negatively associated with smoking. Furthermore, female subjects of normal weight had significantly higher serum enterolactone concentrations than did their underweight or obese peers.
CONCLUSIONS
The serum enterolactone concentration varies widely in the population. Of the variables we examined, the most important determinants of the serum enterolactone concentration were consumption of lignan-containing foods and constipation; however, these appeared to explain only a small part of the variation. Therefore, the role of gut microflora in the metabolism of lignans might be very important. Further studies will also be needed to determine the bioavailability and absorption rate of lignans.
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DOI：
10.1016/s0002-8223(95)00214-6
发表时间：
1995-07-01
影响因子：
--
作者：
HUTCHINS, AM;LAMPE, JW;SLAVIN, JL
通讯作者：
SLAVIN, JL
同位素稀释气相色谱-质谱法测定血浆中的木脂素和异黄酮。
影响因子：
--
作者：
Adlercreutz,H;Fotsis,T;Watanabe,S;Lampe,J;Wahala,K;Makela,T;Hase,T
通讯作者：
Hase,T
两年内木酚素和异黄酮类植物雌激素血清测量的可靠性。
DOI：
--
发表时间：
1998
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Zeleniuch-Jacquotte,A;Adlercreutz,H;Akhmedkhanov,A;Toniolo,P
通讯作者：
Toniolo,P
影响因子：
45.3
作者：
Quella, SK;Loprinzi, CL;Novotny, PJ
通讯作者：
Novotny, PJ