Individuality of the plasma sodium concentration.
Individuality of the plasma sodium concentration.
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血浆钠浓度的个体性。
DOI：
10.1152/ajprenal.00585.2013
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Cohen,DavidM
中科院分区：
文献类型：
--
作者：
Zhang,Zheng;Duckart,Jonathan;Slatore,ChristopherG;Fu,Yi;Petrik,AmandaF;Thorp,MicahL;Cohen,DavidM
Older literature has suggested that the plasma sodium concentration is not individual, that it is neither intrinsic to an individual nor reproducible, longitudinally. We recently observed that the plasma sodium concentration is heritable. Because demonstrable heritability requires individuality of the relevant phenotype, we hypothesized that the plasma sodium concentration was substantially individual. In two large health plan-based cohorts, we demonstrated individuality of the plasma sodium concentration over a 10-yr interval; the intraclass correlation coefficient (ICC) averaged 0.4–0.5. The individuality of plasma sodium increased significantly with age. Plasma sodium individuality was equal to or only slightly less than that for plasma glucose but was less than the individuality for creatinine. The individuality of plasma sodium was further confirmed by comparing the Pearson correlation coefficient for within-individual versus between-individual pairs of sodium determinations and via application of the agreement index. Furthermore, the distribution of all sodium determinations for all participants within a population was similar to the distribution for the mean sodium concentration for individuals within that population. Therefore, the near-normal distribution of plasma sodium measurements within a population is likely not attributable to assay-specific factors but rather to genuine and durable biological variability in the osmotic set point. In aggregate, these data strongly support the individuality of the plasma sodium concentration. They further indicate that serial plasma sodium values for any given individual tend to cluster around a patient-specific set point and that these set points vary among individuals.
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影响因子：
158.5
作者：
Feldman, BJ;Rosenthal, SM;Gitelman, SE
通讯作者：
Gitelman, SE
DOI：
--
发表时间：
1996
期刊：
影响因子：
--
作者：
Ayus Jc;Arieff Ai
通讯作者：
Arieff Ai
正常受试者血清成分长期研究中变异的生物学和分析成分。
影响因子：
9.3
作者：
E. K. Harris;D. DeMets
通讯作者：
D. DeMets
老年人的水分排泄。
DOI：
10.1016/s0889-8529(18)30448-1
发表时间：
1987
影响因子：
4.5
作者：
P. Davis;F. B. Davis
通讯作者：
F. B. Davis
低钠血症：诊断、并发症和治疗，包括 V2 受体拮抗剂
影响因子：
3.2
作者：
E. Elhassan;R. Schrier
通讯作者：
R. Schrier