Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts.
Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts.
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结核病密切接触者中潜伏性结核感染风险可能存在性别差异。
DOI：
10.1016/j.ijid.2022.07.031
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发表时间：
2022-09
影响因子：
8.4
通讯作者：
Rebeiro, Peter F.
中科院分区：
文献类型：
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作者：
Wada, Paul Y.;Costa, Allyson G.;Araujo-Pereira, Mariana;Barreto-Duarte, Beatriz;Souza, Alexandra B.;Rocha, Michael S.;Figueiredo, Marina C.;Turner, Megan M.;Rolla, Valeria C.;Kritski, Afranio L.;Cordeiro-Santos, Marcelo;Andrade, Bruno B.;Sterling, Timothy R.;Rebeiro, Peter F.
男性比女性更多地患上和死于结核病。关于潜伏性结核感染（LTBI）的性别差异的数据较少。我们评估了密切结核病接触者中获得LTBI的潜在性别差异。巴西结核病区域前瞻性观察性研究是一项观察性多中心队列研究，研究对象为经培养确诊的肺结核患者及其密切接触者。参与者于2015年6月至2019年6月从巴西的五个研究中心招募。入组后对密切接触者随访24个月，LTBI定义为基线或6个月时干扰素- γ释放试验（IGRA; QuantiFERON第3代或第4代）阳性。我们进行了单变量、双变量和多变量logistic回归和倾向评分加权模型，以评估密切接触者中出生性别获得LTBI的优势比（OR）和95%置信区间（CI）。在1093名密切接触者中，504名女性（46%）为IGRA阳性，而745名男性中有295名（40%）为IGRA阳性。女性与男性IGRA阳性的未校正OR为1.31（95% CI：1.08-1.58）。双变量调整后，女性与男性的OR值范围为1.19至1.33（P值范围：< 0.01-0.07）。多变量回归和加权模型得出女性与男性的OR相似，分别为1.14（95% CI：0.92-1.41）和1.15（95% CI：0.94-1.40）。巴西结核病密切接触者中LTBI的点估计值在女性中更高，尽管在多变量模型中不太明显。如果在其他环境中证实了LTBI的性别差异，则有必要研究社会行为因素或TB发病机制的潜在差异。
More men than women develop and die of tuberculosis (TB). Fewer data exist on sex differences in latent TB infection (LTBI). We assessed for potential sex differences in LTBI acquisition among close TB contacts. Regional Prospective Observational Research for TB-Brazil is an observational multi-center cohort of individuals with culture-confirmed pulmonary TB and their close contacts. Participants were enrolled from five sites in Brazil from June 2015 - June 2019. Close contacts were followed for 24 months after enrollment, with LTBI defined as a positive interferon- γ release assay (IGRA; QuantiFERON 3rd or 4th generation) at baseline or 6 months. We performed univariate, bivariate, and multivariable logistic regression and propensity-score weighted models to assess odds ratios (OR) and 95% confidence intervals (CI) for LTBI acquisition by birth sex among close contacts. Of 1093, 504 (46%) female close contacts were IGRA positive compared to 295 of 745 (40%) men. The unadjusted OR for IGRA positivity among women vs men was 1.31 (95% CI: 1.08–1.58). Bivariate adjustments yielded ORs in women vs men ranging from 1.19 to 1.33 (P-value range: < 0.01–0.07). Multivariable regression and weighted models yielded similar ORs in women vs men, of 1.14 (95% CI: 0.92–1.41) and 1.15 (95% CI: 0.94–1.40), respectively. The point estimate for LTBI among close TB contacts in Brazil was higher in women, though less pronounced in multivariable models. If the sex difference in LTBI is confirmed in additional settings, studies of possible underlying differences in socio-behavioral factors or TB pathogenesis are warranted.
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影响因子：
5
作者：
Dodd PJ;Looker C;Plumb ID;Bond V;Schaap A;Shanaube K;Muyoyeta M;Vynnycky E;Godfrey-Faussett P;Corbett EL;Beyers N;Ayles H;White RG
通讯作者：
White RG
影响因子：
3.7
作者：
Lindsay RP;Shin SS;Garfein RS;Rusch ML;Novotny TE
通讯作者：
Novotny TE
DOI：
10.1093/cid/ciz1044
发表时间：
2020-10-23
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Reichler MR;Khan A;Yuan Y;Chen B;McAuley J;Mangura B;Sterling TR;Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
通讯作者：
Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
影响因子：
28.2
作者：
Pettit, April C.;Bethel, James;Sterling, Timothy R.
通讯作者：
Sterling, Timothy R.
影响因子：
1.2
作者：
Li, Liang;Greene, Tom
通讯作者：
Greene, Tom