The Association between active and passive smoking and latent tuberculosis infection in adults and children in the united states: results from NHANES.
The Association between active and passive smoking and latent tuberculosis infection in adults and children in the united states: results from NHANES.
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DOI：
10.1371/journal.pone.0093137
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Novotny TE
中科院分区：
文献类型：
--
作者：
Lindsay RP;Shin SS;Garfein RS;Rusch ML;Novotny TE
很少有评估主动吸烟和被动吸烟与结核病之间关系的研究使用生物标记物来衡量吸烟暴露。我们试图在具有代表性的美国成年人和儿童样本中确定主动吸烟和被动吸烟与LTBI之间的联系。我们使用1999年至2000年美国国家健康和营养检查调查数据集和结核菌素皮肤试验数据，评估了20岁的≥成人(n = 3598)和3-19岁的儿童(n = 2943)中可替宁确认的烟雾暴露与潜在结核病感染之间的关系，并估计了那些患有潜在结核感染的人中吸烟暴露的流行率。采用加权多因素Logistic回归分析主动吸烟和被动吸烟与下丘脑损伤之间的关系。1999-2000年，可替宁确诊的主动、被动和非吸烟成人和儿童的LTBI患病率分别为6.0%、5.2%、3.3%和0.3%、1.0%、1.5%。这相当于1999-2000年间美国平民非住院人口中约3,556,000名积极吸烟的成年人和3,379,000名被动吸烟的成人患有LTBI。控制了年龄、性别、社会经济地位、种族、出生地(美国和外国出生)、家庭规模和与结核病患者一起生活过的成年人，成年经常吸烟的人比不吸烟的成年人更有可能患上下呼吸道感染(AOR = 2.31 95%CI1.17-4.55)。与非吸烟者相比，成年被动吸烟者发生腰腿伤的几率也更高，但这种关联没有统计学意义(AOR = 2.0095%CI 0.87-4.60)。在儿童中，无论是主动吸烟还是被动吸烟都与LTBI无关。仅在外国出生的成年人中，主动(AOR = )2.5 6(95%CI 1.2 0~5.45)和被动吸烟(AOR = 2.2 7 95%CI 1.0 9~4.72)与腰腿伤显著相关。在美国，活跃的成年吸烟者以及在外国出生的活跃和被动吸烟者患LTBI的风险都很高。有针对性的吸烟预防和戒烟计划应该包括在全面的国家和国际结核病控制努力中。
Few studies assessing the relationship between active and passive smoking and tuberculosis have used biomarkers to measure smoke exposure. We sought to determine the association between active and passive smoking and LTBI in a representative sample of US adults and children. We used the 1999–2000 US National Health and Nutrition Examination Survey (NHANES) dataset with tuberculin skin test (TST) data to assess the association between cotinine-confirmed smoke exposure and latent tuberculosis infection (LTBI) among adults ages ≥20 years (n = 3598) and children 3–19 years (n = 2943) and estimate the prevalence of smoke exposure among those with LTBI. Weighted multivariate logistic regression was used to measure the associations between active and passive smoking and LTBI. LTBI prevalence in 1999–2000 among cotinine-confirmed active, passive, and non-smoking adults and children was 6.0%, 5.2%, 3.3% and 0.3%, 1.0%, 1.5%, respectively. This corresponds to approximately 3,556,000 active and 3,379,000 passive smoking adults with LTBI in the US civilian non-institutionalized population in 1999–2000. Controlling for age, gender, socioeconomic status, race, birthplace (US vs. foreign-born), household size, and having ever lived with someone with TB, adult active smokers were significantly more likely to have LTBI than non-smoking adults (AOR = 2.31 95% CI 1.17–4.55). Adult passive smokers also had a greater odds of LTBI compared with non-smokers, but this association did not achieve statistical significance (AOR = 2.00 95% CI 0.87–4.60). Neither active or passive smoking was associated with LTBI among children. Among only the foreign-born adults, both active (AOR = 2.56 (95% CI 1.20–5.45) and passive smoking (AOR = 2.27 95% CI 1.09–4.72) were significantly associated with LTBI. Active adult smokers and both foreign-born active and passive smokers in the United States are at elevated risk for LTBI. Targeted smoking prevention and cessation programs should be included in comprehensive national and international TB control efforts.
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影响因子：
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作者：
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通讯作者：
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10.1164/rccm.200701-057oc
发表时间：
2008-02-01
影响因子：
24.7
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DOI：
10.14745/ccdr.v36i00a05
发表时间：
2010-06-01
期刊：
Canada communicable disease report = Releve des maladies transmissibles au Canada
影响因子：
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作者：
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