Effect of Tea Polyphenol Compounds on Anticancer Drugs in Terms of Anti-Tumor Activity, Toxicology, and Pharmacokinetics.
Effect of Tea Polyphenol Compounds on Anticancer Drugs in Terms of Anti-Tumor Activity, Toxicology, and Pharmacokinetics.
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作者：
Cao J;Han J;Xiao H;Qiao J;Han M
多药耐药和各种不良反应一直是肿瘤化疗中的主要问题。近年来，化疗逐渐从单一药物治疗过渡到多药治疗。因此，鸡尾酒药物战略得到了更多的认可和更广泛的使用。据信，适当配制的药物组合比单一药物具有更大的治疗功效。茶是癌症患者和公众消费的流行饮料，因为它对健康有益。绿色茶中的主要生物活性分子是儿茶素，一种黄烷醇。绿色茶提取物或绿色茶儿茶素与抗癌化合物的组合在癌症治疗中受到了更多的关注。以往的研究表明，化疗药物与绿色茶提取物或茶多酚的组合可以协同增强癌症患者的治疗效果并减少抗癌药物的不良副作用。本文综述了绿色茶多酚与化疗药物联合应用对肿瘤细胞的抗肿瘤活性、毒理学和药代动力学的影响。我们相信，多药癌症治疗与绿色茶儿茶素的组合可以提高治疗效果并减少负面副作用。
Multidrug resistance and various adverse side effects have long been major problems in cancer chemotherapy. Recently, chemotherapy has gradually transitioned from mono-substance therapy to multidrug therapy. As a result, the drug cocktail strategy has gained more recognition and wider use. It is believed that properly-formulated drug combinations have greater therapeutic efficacy than single drugs. Tea is a popular beverage consumed by cancer patients and the general public for its perceived health benefits. The major bioactive molecules in green tea are catechins, a class of flavanols. The combination of green tea extract or green tea catechins and anticancer compounds has been paid more attention in cancer treatment. Previous studies demonstrated that the combination of chemotherapeutic drugs and green tea extract or tea polyphenols could synergistically enhance treatment efficacy and reduce the adverse side effects of anticancer drugs in cancer patients. In this review, we summarize the experimental evidence regarding the effects of green tea-derived polyphenols in conjunction with chemotherapeutic drugs on anti-tumor activity, toxicology, and pharmacokinetics. We believe that the combination of multidrug cancer treatment with green tea catechins may improve treatment efficacy and diminish negative side effects.
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影响因子：
3
作者：
Bannerman, Bret;Xu, Ling;Jones, Matthew;Tsu, Christopher;Yu, Jie;Hales, Paul;Monbaliu, Johan;Fleming, Paul;Dick, Lawrence;Manfredi, Mark;Claiborne, Christopher;Bolen, Joseph;Kupperman, Erik;Berger, Allison
通讯作者：
Berger, Allison
影响因子：
11.5
作者：
Adhami, Vaqar Mustafa;Malik, Arshi;Mukhtar, Hasan
通讯作者：
Mukhtar, Hasan
影响因子：
5.6
作者：
Chan, MM;Soprano, KJ;Fong, D
通讯作者：
Fong, D
影响因子：
6.6
作者：
Fujiki, H
通讯作者：
Fujiki, H
影响因子：
3.2
作者：
Glynn SJ;Gaffney KJ;Sainz MA;Louie SG;Petasis NA
通讯作者：
Petasis NA