Overweight, obesity, and individual symptoms of depression: A multicohort study with replication in UK Biobank.
Overweight, obesity, and individual symptoms of depression: A multicohort study with replication in UK Biobank.
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DOI：
10.1016/j.bbi.2022.07.009
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发表时间：
2022-10
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影响因子：
--
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中科院分区：
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超重与抑郁之间的关联是否可归因于特定的抑郁症状，而不是整体的抑郁，目前仍不确定。肥胖与一系列明显的抑郁症状有关，这些症状的特征是情绪低落，做事没有兴趣，感觉不足，缺乏精力。肥胖与其他抑郁症状和整体抑郁的关联较弱。全身性炎症和肥胖相关的发病率可能是重要的机制。肥胖与抑郁风险增加有关，但这种联系在多大程度上是症状特异性的尚不清楚。我们研究了超重和肥胖与个体抑郁症状的关系。我们汇集了来自15个基于人群的队列的数据，包括57,532名18至100岁的个体。主要分析在英国生物银行的独立队列研究中得到了重复（n = 122,341，年龄范围38至72岁）。在基线时评估身高和体重，并计算体重指数（BMI）。使用有效的自我报告测量，在16个横断面研究中确定了24种抑郁症状，在7个前瞻性队列研究中确定了两次（平均随访3.2年）。在主要队列的汇总分析中，22045名（38.3%）参与者超重（BMI在25至29.9 kg/m2之间），12025名（20.9%）I级肥胖（BMI在30至34.9 kg/m2之间），7467名（13.0%）II-III级肥胖（BMI≥35 kg/m2）；7046人（12.3%）被归类为抑郁症。多变量调整后，I类肥胖与1.11倍（95%可信区间1.01-1.22）相关，II-III类肥胖与1.31倍（1.16-1.49）相关。在症状特异性分析中，24种抑郁症状中的4种（“无法行动/缺乏能量”、“做事缺乏兴趣”、“自我感觉不好”和“感到沮丧”）明显存在强烈的关联，在混杂因素调整后，具有上述3种或4种症状的比值比在肥胖I级个体中为1.32(1.10-1.57)，在肥胖II-III级个体中为1.70（1.34-2.14）。c反应蛋白升高和21种肥胖相关疾病解释了23% - 31%的关联。症状特异性关联在纵向分析中得到证实，肥胖先于症状出现，在女性中比在男性中更强，并且在UK Biobank中得到了重复。肥胖与一系列明显的抑郁症状有关。这些关联部分可以通过全身性炎症和肥胖相关的发病率来解释。了解这种与肥胖相关的症状及其潜在的生物学相关性，可以为肥胖和抑郁症的合并症提供更好的靶向治疗。
Whether the association between excess body weight and depression is attributable to specific depressive symptoms rather than overall depression remains uncertain. Obesity was associated with a distinct set of depressive symptoms characterised by low mood, little interest in doing things, feelings of inadequacy, and lack of energy. The associations of obesity with other depressive symptoms and overall depression were weaker. Systemic inflammation and obesity-related morbidity may be important mechanisms. Obesity is associated with increased risk of depression, but the extent to which this association is symptom-specific is unknown. We examined the associations of overweight and obesity with individual depressive symptoms. We pooled data from 15 population-based cohorts comprising 57,532 individuals aged 18 to 100 years at study entry. Primary analyses were replicated in an independent cohort, the UK Biobank study (n = 122,341, age range 38 to 72). Height and weight were assessed at baseline and body mass index (BMI) was computed. Using validated self-report measures, 24 depressive symptoms were ascertained once in 16 cross-sectional, and twice in 7 prospective cohort studies (mean follow-up 3.2 years). In the pooled analysis of the primary cohorts, 22,045 (38.3 %) participants were overweight (BMI between 25 and 29.9 kg/m2), 12,025 (20.9 %) class I obese (BMI between 30 and 34.9 kg/m2), 7,467 (13.0 %) class II-III obese (BMI ≥ 35 kg/m2); and 7,046 (12.3 %) were classified as depressed. After multivariable adjustment, obesity class I was cross-sectionally associated with 1.11-fold (95 % confidence interval 1.01–1.22), and obesity class II-III with 1.31-fold (1.16–1.49) higher odds of overall depression. In symptom-specific analyses, robust associations were apparent for 4 of the 24 depressive symptoms (‘could not get going/lack of energy’, ‘little interest in doing things’, ‘feeling bad about yourself, and ‘feeling depressed’), with confounder-adjusted odds ratios of having 3 or 4 of these symptoms being 1.32 (1.10–1.57) for individuals with obesity class I, and 1.70 (1.34–2.14) for those with obesity class II-III. Elevated C-reactive protein and 21 obesity-related diseases explained 23 %-31 % of these associations. Symptom-specific associations were confirmed in longitudinal analyses where obesity preceded symptom onset, were stronger in women compared with men, and were replicated in UK Biobank. Obesity is associated with a distinct set of depressive symptoms. These associations are partially explained by systemic inflammation and obesity-related morbidity. Awareness of this obesity-related symptom profile and its underlying biological correlates may inform better targeted treatments for comorbid obesity and depression.
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影响因子：
6.9
作者：
Badini I;Coleman JRI;Hagenaars SP;Hotopf M;Breen G;Lewis CM;Fabbri C
通讯作者：
Fabbri C
DOI：
10.1038/oby.2002.86
发表时间：
2002-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Anderson, JW;Greenway, FL;O'Neil, PM
通讯作者：
O'Neil, PM
影响因子：
17.7
作者：
Cuijpers, Pim;Vogelzangs, Nicole;Penninx, Brenda W.
通讯作者：
Penninx, Brenda W.
影响因子：
11
作者：
Milaneschi, Yuri;Simmons, W Kyle;Penninx, Brenda Wjh
通讯作者：
Penninx, Brenda Wjh
影响因子：
6.9
作者：
Brailean, Anamaria;Curtis, Jessica;Hotopf, Matthew
通讯作者：
Hotopf, Matthew