Measurement of glycerol turnover by infusion of nonisotopic glycerol in normal and injured subjects.
Measurement of glycerol turnover by infusion of nonisotopic glycerol in normal and injured subjects.
复制标题
通过在正常和受伤受试者中输注非同位素甘油来测量甘油周转率。
DOI:
10.1152/ajpendo.1984.247.3.e405
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发表时间:
1984
期刊:
影响因子:
--
通讯作者:
Kinney,JM
中科院分区:
文献类型:
--
作者:
Carpentier,YA;Jeevanandam,M;Robin,AP;Nordenstrom,J;Burr,RE;Leibel,RL;Hirsch,J;Elwyn,DH;Kinney,JM
A new technique for measuring glycerol turnover in human subjects is presented using a staged infusion of unlabeled glycerol. A total of 105 measurements was made in normal subjects and postoperative or acutely ill patients. The relation between glycerol turnover rate (Rt) and concentration (C) (Rt = 31 + 2.07C) from 80 staged infusion measurements in 21 normal subjects did not differ significantly from observations of others made by isotope dilution. In 11 patients, glycerol turnover was also measured by dilution of isotopic glycerol. Mean values did not differ significantly between the two methods. The average difference, regardless of sign, for individual values was 17%. This agreement tends to validate the assumptions of both methods. Advantages of the staged infusion method are that it is quicker and easier to perform and does not entail a risk due to administration of radioactive materials. Evidence obtained in this study from a three-stage procedure indicates that satisfactory information may be obtained from a two-stage infusion at successive rates of 250 and 600 μmol/min for 70 min each, with a prime of 2 mmol given as a bolus at the start of each stage.isotope dilution; glycerol clearance; glycerol concentration; lipolysis; futile cycleSubmitted on December 27, 1983Accepted on April 18, 1984
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DOI:
10.1152/ajplegacy.1968.215.4.865
发表时间:
1968
期刊:
The American journal of physiology
影响因子:
--
作者:
E. N. Bergman
通讯作者:
E. N. Bergman
DOI:
10.1016/0026-0495(76)90091-3
发表时间:
1976
期刊:
Metabolism: clinical and experimental
影响因子:
--
作者:
W. A. Shaw;T. Issekutz;B. Issekutz
通讯作者:
B. Issekutz
DOI:
10.1016/0026-0495(80)90042-6
发表时间:
1980
期刊:
Metabolism: clinical and experimental
影响因子:
--
作者:
Y. Carpentier;J. Askanazi;D. Elwyn;F. Gump;J. Nordenström;J. Kinney
通讯作者:
J. Kinney
影响因子:
2.1
作者:
M. Kallai;K. Norwich;G. Steiner
通讯作者:
G. Steiner
影响因子:
--
作者:
B. Winkler;R. Steele;N. Altszuler
通讯作者:
N. Altszuler