Progressive patterning precedes somite segmentation in the Mexican axolotl (Ambystoma mexicanum).
Progressive patterning precedes somite segmentation in the Mexican axolotl (Ambystoma mexicanum).
复制标题
在墨西哥蝾螈（Ambystoma mexicanum）中，渐进模式先于体节分割。
DOI：
10.1016/0012-1606(88)90232-1
复制
发表时间：
1988
影响因子：
2.7
通讯作者：
A. Graveson
中科院分区：
文献类型：
--
作者：
John B. Armstrong;A. Graveson
从中期神经胚开始，一波体节分割通过轴蝾螈身体在头尾方向。在20°C下，每2.57小时形成一个体节。前体节中胚层的命运作图表明，接下来几个体节的原基占据了几乎相同的空间，因为它们在分割后，但剩余的体节密集地堆积在尾芽的尖端。在37 ° C和38.5°C下的短暂热冲击揭示了在这两个区域中的第一个区域内，对冲击的敏感性是分级的，最接近最后形成的体节的原基表现出最大的抵抗力。然而，在密集包装的顶端（包装区）内的原基也表现出抵抗力，或者有足够的时间来修复损伤。我们建议，一旦细胞已经离开包装区，他们进行渐进的图案，使他们越来越不敏感的破坏性影响的热休克，并最终在玫瑰花结的形成。
Beginning at mid-neurulation, a wave of somite segmentation passes down the axolotl body axis in a cephalocaudal direction. At 20°C a somite forms every 2.57 hr. Fate-mapping of the presomitic mesoderm indicates that the primordia for the next few somites occupy nearly the same space that they will after segmentation, but that the remaining somites are densely packed in tip of the tail bud. Brief heat shocks at 37 and 38.5°C reveal that within the first of these two zones, there is a graded sensitivity to the shock, with the primordia closest to the last-formed somite showing the greatest resistance. However, primordia within the densely packed tip (the packing zone) also appear resistant, or have sufficient time to repair the damage. We propose that once cells have left the packing zone, they undergo progressive patterning which renders them increasingly insensitive to the disruptive effects of heat shock, and culminates in rosette formation.
蝾螈中胚层形态发生所需的蛋白质前节波的实验证据。
影响因子：
2.7
作者：
Gillespie,LL;Armstrong,JB;Steinberg,MS
通讯作者：
Steinberg,MS