How COVID-19 induces cytokine storm with high mortality.
How COVID-19 induces cytokine storm with high mortality.
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DOI：
10.1186/s41232-020-00146-3
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发表时间：
2020
影响因子：
8.1
通讯作者：
Hirano T
中科院分区：
文献类型：
--
作者：
Hojyo S;Uchida M;Tanaka K;Hasebe R;Tanaka Y;Murakami M;Hirano T
由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的新型冠状病毒病2019（COVID-19）首次在中国武汉报道，但已迅速蔓延至全球。一些COVID-19患者会出现严重的急性呼吸窘迫综合征（ARDS）症状，死亡率很高。这种高严重程度依赖于细胞因子风暴，最可能由白细胞介素-6（IL-6）放大器诱导，这是一种调节核因子κ B（NF-κB）通路的超活化机制，并受到非免疫细胞（包括肺泡上皮细胞和内皮细胞）中IL-6信号转导和转录激活因子3（STAT 3）和NF-κB信号传导的同时活化的刺激。我们假设IL-6-STAT 3信号传导是COVID-19中细胞因子风暴的有希望的治疗靶点，因为IL-6是主要的STAT 3刺激物，特别是在炎症期间。本文就COVID-19患者ARDS的发病机制和潜在治疗靶点进行综述。
The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some COVID-19 patients encounter a severe symptom of acute respiratory distress syndrome (ARDS) with high mortality. This high severity is dependent on a cytokine storm, most likely induced by the interleukin-6 (IL-6) amplifier, which is hyper-activation machinery that regulates the nuclear factor kappa B (NF-κB) pathway and stimulated by the simultaneous activation of IL-6-signal transducer and activator of transcription 3 (STAT3) and NF-κB signaling in non-immune cells including alveolar epithelial cells and endothelial cells. We hypothesize that IL-6-STAT3 signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL-6 is a major STAT3 stimulator, particularly during inflammation. We herein review the pathogenic mechanism and potential therapeutic targets of ARDS in COVID-19 patients.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
19.6
作者：
Chu KH;Tsang WK;Tang CS;Lam MF;Lai FM;To KF;Fung KS;Tang HL;Yan WW;Chan HW;Lai TS;Tong KL;Lai KN
通讯作者：
Lai KN
影响因子：
158.5
作者：
De Benedetti, Fabrizio;Brunner, Hermine I.;Martini, Alberto
通讯作者：
Martini, Alberto
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin