Neural primacy of the salience processing system in schizophrenia.
Neural primacy of the salience processing system in schizophrenia.
复制标题
DOI：
10.1016/j.neuron.2013.06.027
复制
发表时间：
2013-08-21
期刊：
影响因子：
16.2
通讯作者：
Liddle PF
中科院分区：
文献类型：
--
作者：
Palaniyappan L;Simmonite M;White TP;Liddle EB;Liddle PF
对于有效的信息处理，两个大规模的分布式神经网络似乎是至关重要的：一个是固定在背外侧前额叶皮质(DLPFC)的多模式执行系统，另一个是固定在前岛上的凸起系统。分布式网络之间的异常相互作用是精神分裂症等精神障碍的一个特征。我们使用静息fMRI的全脑Granger因果模型，观察到精神分裂症患者脑岛和DLPFC之间的前馈和相互影响都显著失败。此外，在患者中也可以看到双侧视觉皮质对脑岛的直接影响显著失败。这些发现提供了令人信服的证据，证明了精神病临床表现中的突出-执行环路的崩溃。此外，这也为我们经常观察到的“额叶低效”提供了一个简约的解释，即当精神分裂症患者获得显著或新颖的信息时，未能招募到前额叶系统。静息状态下fMRI全脑Granger因果分析出现显著-执行环路，DLPFC对精神分裂症患者的显著网络有抑制作用，视觉皮质对精神分裂症患者的显著网络没有影响。研究表明，在精神分裂症患者中，涉及前岛叶和背外侧前额叶皮质的相互显著执行环路随着感觉区域对显著处理系统的分级影响的失败而解体。
For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (DLPFC) and a salience system anchored on the anterior insula. Aberrant interaction among distributed networks is a feature of psychiatric disorders such as schizophrenia. We used whole-brain Granger causal modeling using resting fMRI and observed a significant failure of both the feedforward and reciprocal influence between the insula and the DLPFC in schizophrenia. Further, a significant failure of directed influence from bilateral visual cortices to the insula was also seen in patients. These findings provide compelling evidence for a breakdown of the salience-execution loop in the clinical expression of psychosis. In addition, this offers a parsimonious explanation for the often-observed “frontal inefficiency,” the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. A salience-executive loop emerges on fMRI whole-brain Granger causal analysis At rest, DLPFC has inhibitory Granger influence on the salience network In schizophrenia, the salience-executive interaction is diminished Visual cortex fails to influence the salience network in schizophrenia Palaniyappan et al. show that in patients with schizophrenia, a reciprocal salience-execution loop involving anterior insula and dorsolateral prefrontal cortex disintegrates along with a failure of hierarchical influence from sensory regions to the salience processing system.
登录
查看更多内容
影响因子：
2.9
作者：
Klein TA;Ullsperger M;Danielmeier C
通讯作者：
Danielmeier C
影响因子：
3.7
作者：
Cole, David M.;Oei, Nicole Y. L.;Beckmann, Christian F.
通讯作者：
Beckmann, Christian F.
影响因子：
5.7
作者：
Brookes, M. J.;Liddle, E. B.;Morris, P. G.
通讯作者：
Morris, P. G.
影响因子：
--
作者：
Guller, Yelena;Ferrarelli, Fabio;Shackman, Alexander J.;Sarasso, Simone;Peterson, Michael J.;Langheim, Frederick J.;Meyerand, Mary E.;Tononi, Giulio;Postle, Bradley R.
通讯作者：
Postle, Bradley R.
影响因子：
10.6
作者：
Forget, Benoit;Pushparaj, Abhiram;Le Foll, Bernard
通讯作者：
Le Foll, Bernard