Error awareness and the insula: links to neurological and psychiatric diseases.
Error awareness and the insula: links to neurological and psychiatric diseases.
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DOI：
10.3389/fnhum.2013.00014
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发表时间：
2013
影响因子：
2.9
通讯作者：
Danielmeier C
中科院分区：
文献类型：
--
作者：
Klein TA;Ullsperger M;Danielmeier C
意识到自己犯下的错误可能对策略性行为和神经元调整至关重要，以避免将来发生类似的错误。本文综述了健康受试者的有意识错误知觉（“错误意识”）以及错误意识与神经和精神疾病之间的关系。我们首先讨论了健康受试者的错误意识的主要研究结果。一个大脑区域，似乎始终参与错误意识过程，是大脑皮层，这也提供了一个链接到临床条件在这里审查。然后，我们专注于一个神经系统的条件，其核心要素是一个受损的认识神经系统的后果的疾病：病感失认偏瘫（AHP）。岛叶皮层与错误意识和AHP都有关系，前岛叶区域参与有意识的错误处理，后岛叶区域与AHP相关。除了细胞结构和连接数据，这反映了从前到后的神经元内的功能和结构梯度。此外，报告了一些精神疾病中的错误意识和缺乏洞察力的研究。特别是在精神分裂症、注意力缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）中，表现监测系统似乎受损，因此有意识的错误感知可能会改变。
Becoming aware of errors that one has committed might be crucial for strategic behavioral and neuronal adjustments to avoid similar errors in the future. This review addresses conscious error perception (“error awareness”) in healthy subjects as well as the relationship between error awareness and neurological and psychiatric diseases. We first discuss the main findings on error awareness in healthy subjects. A brain region, that appears consistently involved in error awareness processes, is the insula, which also provides a link to the clinical conditions reviewed here. Then we focus on a neurological condition whose core element is an impaired awareness for neurological consequences of a disease: anosognosia for hemiplegia (AHP). The insular cortex has been implicated in both error awareness and AHP, with anterior insular regions being involved in conscious error processing and more posterior areas being related to AHP. In addition to cytoarchitectonic and connectivity data, this reflects a functional and structural gradient within the insula from anterior to posterior. Furthermore, studies dealing with error awareness and lack of insight in a number of psychiatric diseases are reported. Especially in schizophrenia, attention-deficit hyperactivity disorder, (ADHD) and autism spectrum disorders (ASD) the performance monitoring system seems impaired, thus conscious error perception might be altered.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
3.8
作者：
Danielmeier C;Ullsperger M
通讯作者：
Ullsperger M
影响因子：
4.8
作者：
Cerliani, Leonardo;Thomas, Rajat M.;Jbabdi, Saad;Siero, Jeroen C. W.;Nanetti, Luca;Crippa, Alessandro;Gazzola, Valeria;D'Arceuil, Helen;Keysers, Christian
通讯作者：
Keysers, Christian
影响因子：
2.9
作者：
de Bruijn, Ellen R. A.;Sabbe, Bernard G. C.;Verkes, Robbert J.
通讯作者：
Verkes, Robbert J.