Human Hepatocellular response in Cholestatic Liver Diseases.
Human Hepatocellular response in Cholestatic Liver Diseases.
复制标题
DOI：
10.1080/15476278.2023.2247576
复制
发表时间：
2023-12-31
期刊：
影响因子：
2.3
通讯作者：
Faccioli, Lanuza A. P.
中科院分区：
文献类型：
--
作者：
Ortiz, Kimberly;Cetin, Zeliha;Sun, Yiyue;Hu, Zhiping;Kurihara, Takeshi;Tafaleng, Edgar N. N.;Florentino, Rodrigo M. M.;Ostrowska, Alina;Soto-Gutierrez, Alejandro;Faccioli, Lanuza A. P.
关键词：
原发性胆管炎(PBC)和原发性硬化性胆管炎(PSC)是胆汁淤积性肝病(CLD)中最常见的两种类型，可导致肝肠梗阻、胆汁酸蓄积和肝毒性。肝细胞对CLD的反应和应对机制在很大程度上尚不清楚。这项研究包括从PBC和PSC患者的移植肝中分离出的肝细胞的特征。我们检测了从PBC和PSC患者的移植肝中分离的原代人肝细胞(PHHs)中肝细胞特异性基因的表达、细胞内胆汁酸(BA)水平和氧化应激，并将它们与正常对照人肝细胞进行了比较。我们的发现为慢性肝病肝细胞对胆汁淤积的反应提供了有价值的初步见解，并有助于支持将PHHs用作治疗这些疾病的实验工具。
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the most common types of cholestatic liver disease (CLD), result in enterohepatic obstruction, bile acid accumulation, and hepatotoxicity. The mechanisms by which hepatocytes respond to and cope with CLD remain largely unexplored. This study includes the characterization of hepatocytes isolated from explanted livers of patients with PBC and PSC. We examined the expression of hepatocyte-specific genes, intracellular bile acid (BA) levels, and oxidative stress in primary-human-hepatocytes (PHHs) isolated from explanted livers of patients with PBC and PSC and compared them with control normal human hepatocytes. Our findings provide valuable initial insights into the hepatocellular response to cholestasis in CLD and help support the use of PHHs as an experimental tool for these diseases.
登录
查看更多内容
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1016/j.jhepr.2021.100286
发表时间：
2021-06
期刊：
JHEP reports : innovation in hepatology
影响因子：
--
作者：
Cazzagon N;Sarcognato S;Floreani A;Corrà G;De Martin S;Guzzardo V;Russo FP;Guido M
通讯作者：
Guido M
影响因子：
3.5
作者：
TOVEY, MG;GUGENHEIM, J;REYNES, M
通讯作者：
REYNES, M
影响因子：
4.6
作者：
Milkiewicz M;Klak M;Kempinska-Podhorodecka A;Wiechowska-Kozlowska A;Urasinska E;Blatkiewicz M;Wunsch E;Elias E;Milkiewicz P
通讯作者：
Milkiewicz P
影响因子：
8
作者：
Cai, Shi-Ying;Ouyang, Xinshou;Boyer, James L.
通讯作者：
Boyer, James L.