Searching for differentially expressed gene combinations.

Searching for differentially expressed gene combinations.
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DOI:
10.1186/gb-2005-6-10-r88
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发表时间:
2005
期刊:
影响因子:
12.3
通讯作者:
Parmigiani G
Parmigiani G
中科院分区:
生物学1区
文献类型:
--
作者:
Dettling M;Gabrielson E;Parmigiani G

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CorScor是一种鉴定联合差异表达基因对的新方法。它可以用来检测表型相关的依赖和基因之间的相互作用。我们提出了“CorScor”,一种识别具有联合差异表达的基因对的新方法。这被定义为在双变量中具有良好表型歧视的情况,但在两个边缘分布中没有。CorScor可用于检测表型相关的依赖性和基因之间的相互作用。我们易于解释的方法可扩展到当前的微阵列尺寸,并在几个癌症基因表达数据集上产生有希望的结果。
CorScor is a novel approach to identifying gene pairs with joint differential expression. It can be used to detect phenotype-related dependencies and interactions among genes. We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.
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