Ozone therapy in COVID-19: A narrative review.
Ozone therapy in COVID-19: A narrative review.
复制标题
COVID-19中的臭氧治疗：叙述性综述。
DOI：
10.1016/j.virusres.2020.198207
复制
发表时间：
2021-01-02
期刊：
影响因子：
5
通讯作者：
De Rosa FG
中科院分区：
文献类型：
--
作者：
Cattel F;Giordano S;Bertiond C;Lupia T;Corcione S;Scaldaferri M;Angelone L;De Rosa FG
臭氧疗法似乎在SARS-CoV-2方案中具有免疫学作用，因为细胞因子和干扰素的调节，包括伽玛干扰素的诱导。臭氧通过抑制病毒复制和直接灭活病毒而发挥抗病毒活性。臭氧是一种抗病毒药物增强剂，不是抗病毒药物的替代品。臭氧的给药途径有直接静脉给药、主要自体血液疗法和血管外血液氧合-臭氧氧化。臭氧和抗病毒药物的联合治疗显示出炎症和肺损伤的减少。这篇叙述性综述的主要目的是描述有关臭氧对新冠肺炎患者可能的抗病毒活性的现有证据，以及它通过医院方案的治疗适用性。在SARS-CoV-2肺炎的不同可能治疗方法中，臭氧疗法似乎具有免疫学作用，因为它调节了细胞因子和干扰素，包括诱导伽玛干扰素。一些数据表明，臭氧疗法在SARS中可能发挥作用，或者作为单一疗法，或者更现实地，作为标准治疗方案的辅助疗法；因此，人们对臭氧疗法在新冠肺炎治疗中的作用越来越感兴趣。搜索范围仅限于2011年1月至2020年7月发表的文章。在找到的280篇关于臭氧治疗的文章中，13篇被选择并进行叙述性综述。臭氧通过抑制病毒复制和直接灭活病毒而发挥抗病毒活性。臭氧是一种抗病毒药物增强剂，不是抗病毒药物的替代品。臭氧和抗病毒药物的联合治疗显示出炎症和肺损伤的减少。臭氧的给药途径有直接静脉给药、主要自体血液疗法和血管外血液氧合-臭氧氧化。全身臭氧治疗在控制炎症、刺激免疫、抗病毒活性、预防急性冠脉综合征和缺血再灌注损伤等方面似乎是有效的，从而为免疫治疗提供了一种新的方法学。对于新冠肺炎阳性患者，全身臭氧治疗联合抗病毒药物可能是合理的、有效的和协同的。
Ozone therapy seems to have an immunological role within SARS-CoV-2 regimens, because of the modulation of cytokines and interferons, including the induction of gamma interferon. Ozone exerts antiviral activity through the inhibition of viral replication and direct inactivation of viruses. Ozone is an antiviral drug enhancer and is not an alternative to antiviral drugs. The routes of ozone administration are direct intravenous, major autohaemotherapy and extravascular blood oxygenation-ozonation. Combined treatment with involving ozone and antivirals demonstrated a reduction in inflammation and lung damage. The main objective of this narrative review is to describe the available evidence on the possible antiviral activity of ozone in patients with COVID-19 and its therapeutic applicability through hospital protocols. Amongst different possible therapies for SARS-CoV-2 pneumonia, ozone therapy seems to have an immunological role because of the modulation of cytokines and interferons, including the induction of gamma interferon. Some data suggest the possible role of ozone therapy in SARS, either as a monotherapy or, more realistically, as an adjunct to standard treatment regimens; therefore, there is increasing interest in the role of ozone therapy in COVID-19 treatment The PubMed and Scopus databases and the Italian Scientific Society of Oxygen Ozone Therapy website were used to identify articles focused on ozone therapy. The search was limited to articles published from January 2011 to July 2020. Of 280 articles found on ozone therapy, 13 were selected and narratively reviewed. Ozone exerts antiviral activity through the inhibition of viral replication and direct inactivation of viruses. Ozone is an antiviral drug enhancer and is not an alternative to antiviral drugs. Combined treatment with involving ozone and antivirals demonstrated a reduction in inflammation and lung damage. The routes of ozone administration are direct intravenous, major autohaemotherapy and extravascular blood oxygenation-ozonation. Systemic ozone therapy seems useful in controlling inflammation, stimulating immunity and as antiviral activity and providing protection from acute coronary syndromes and ischaemia reperfusion damage, thus suggesting a new methodology of immune therapy. Systemic ozone therapy in combination with antivirals in COVID-19-positive patients may be justified, helpful and synergic.
登录
查看更多内容
影响因子：
4.6
作者：
Lupia, Tommaso;Scabini, Silvia;Corcione, Silvia
通讯作者：
Corcione, Silvia
影响因子：
56.9
作者：
Yan, Renhong;Zhang, Yuanyuan;Zhou, Qiang
通讯作者：
Zhou, Qiang
影响因子：
2.9
作者：
Bocci V;Zanardi I;Travagli V
通讯作者：
Travagli V
DOI：
10.4103/0976-9668.82319
发表时间：
2011-01
期刊：
Journal of natural science, biology, and medicine
影响因子：
--
作者：
Elvis AM;Ekta JS
通讯作者：
Ekta JS
DOI：
10.26355/eurrev_201811_16432
发表时间：
2018-11-01
影响因子：
3.3
作者：
Tirelli, U.;Cirrito, C.;Berretta, M.
通讯作者：
Berretta, M.