The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer.
The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer.
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DOI：
10.1186/1471-2407-13-43
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发表时间：
2013-02-01
期刊：
影响因子：
3.8
通讯作者：
Lee YS
中科院分区：
文献类型：
--
作者：
Oh SY;Kwon HC;Kim SH;Lee S;Lee JH;Hwang JA;Hong SH;Graves CA;Camphausen K;Kim HJ;Lee YS
本研究的目的是评估血管内皮生长因子（VEGF）单核苷酸多态性（SNP）与奥沙利铂、5-氟尿嘧啶和亚叶酸钙（FOLFOX）治疗的晚期胃癌患者临床结局之间的关系。从全血中提取基因组DNA，通过PCR分析6种VEGF基因多态性（− 2578 C/A、-2489 C/T、-1498 T/C、-634 G/C、+936 C/T和+1612 G/A）。采用酶联免疫法测定血清VEGF水平。VEGF-634 G/C基因多态性G/G基因型患者的缓解率（22.2%）低于G/C或C/C基因型患者（32.3%，51.1%，P = 0.034）。VEGF-634 G/C多态性G/C + C/C基因型患者的无进展生存期（PFS）为4.9个月，而G/G基因型患者的PFS为3.5个月（P = 0.043，对数秩检验）。多因素分析表明，VEGF-634 G/C多态性G/G基因型是影响患者预后的独立因素（危险比1.497，P = 0.017）。提示VEGF-634 G/C多态性G/G基因型与进展期胃癌患者血清VEGF水平升高、临床预后差有关。
The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX). Genomic DNA was isolated from whole blood, and six VEGF (−2578C/A, -2489C/T, -1498 T/C, -634 G/C, +936C/T, and +1612 G/A) gene polymorphisms were analyzed by PCR. Levels of serum VEGF were measured using enzyme-linked immunoassays. Patients with G/G genotype for VEGF -634 G/C gene polymorphism showed a lower response rate (22.2%) than those with G/C or C/C genotype (32.3%, 51.1%; P = 0.034). Patients with the VEGF -634 G/C polymorphism G/C + C/C genotype had a longer progression free survival (PFS) of 4.9 months, compared with the PFS of 3.5 months for those with the G/G (P = 0.043, log-rank test). By multivariate analysis, this G/G genotype of VEGF -634 G/C polymorphism was identified as an independent prognostic factor (Hazard ratio 1.497, P = 0.017). Our data suggest that G/G genotype of VEGF -634 G/C polymorphism is related to the higher serum levels of VEGF, and poor clinical outcome in advanced gastric cancer patients.
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