Potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin.
Potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin.
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DOI：
10.1177/0269881119867607
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Johnson MW
中科院分区：
文献类型：
--
作者：
Dolan SB;Berry MS;Johnson PS;Johnson MW
人们对使用催产素作为精神疾病（包括物质使用障碍）的药物疗法越来越感兴趣。关于催产素的强化功效的数据有限，这是新药物治疗的必要考虑因素，特别是在物质使用人群中。本研究旨在通过评估行为经济需求和主观效应来确定鼻内给药催产素与安慰剂的潜在强化效应。23名健康成人（n = 23）参加了一项双盲、重复测量的实验室研究，他们在两个疗程中随机接受鼻内催产素（40 IU）或安慰剂。在两次会议结束时，参与者都完成了假设的药品购买任务。在整个疗程中，对主观和生理效果进行了评估。购买任务的需求曲线分析显示，在较低的价格下，催产素相对于安慰剂的购买量中位数略高。生理和主观效应在催产素和安慰剂之间没有显著差异。然而，与安慰剂相比，观察到对催产素的药物偏好有一个不显著的趋势。在药物喜好的差异（催产素和安慰剂之间）和最低价格购买的差异（催产素和安慰剂之间）之间存在显著的正相关。这些数据表明，鼻内催产素可能有有限的强化和滥用相关的主观效应。考虑到样本小，与安慰剂相比，催产素的药物喜好程度较高，需求与药物喜好之间存在正相关关系，催产素可能会在一部分参与者中产生强化效应。因此，对催产素强化的进一步研究是必要的。
There has been growing interest in the use of oxytocin as a pharmacotherapy for psychiatric disorders, including substance use disorder. Limited data exist regarding oxytocin’s reinforcing efficacy, which is a necessary consideration for novel pharmacotherapies, especially in substance-using populations. This study aimed to determine the potential reinforcing effects of intranasally-administered oxytocin versus placebo by assessing behavioral economic demand and subjective effects. Healthy adults (n = 23) participated in a double-blind, repeated-measures, laboratory study wherein they received intranasal oxytocin (40 IU) or placebo in a randomized order across two sessions. Participants completed hypothetical drug purchasing tasks at the conclusion of both sessions. Throughout both sessions, subjective and physiological effects were assessed. Demand curve analysis of purchasing tasks revealed moderately greater median purchasing for oxytocin relative to placebo at low prices. Physiological and subjective effects did not significantly differ between oxytocin and placebo. However, a non-significant trend was observed for moderately greater drug liking for oxytocin relative to placebo. There was a significant, positive correlation between the difference in drug liking (between oxytocin and placebo) and the difference in lowest-price purchasing (between oxytocin and placebo). These data suggest the potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin. Given the small sample, the moderately greater drug liking of oxytocin compared to placebo, and the positive relation between demand and drug liking, it is possible that oxytocin may produce reinforcing effects in a subset of participants. Therefore, additional studies of oxytocin reinforcement are warranted.
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影响因子：
6.2
作者：
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