Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery.
Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery.
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心脏手术中辅助使用卡培立肽（hANP）保护心肌的实验研究。
DOI：
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发表时间：
2005
影响因子：
1.3
通讯作者：
S. Wakui
中科院分区：
文献类型：
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作者：
S. Wakui
背景
近年来，人心钠素(HANP)在内科和外科领域发挥了多种有益作用。然而，hANP对心肌缺血再灌注损伤的直接保护作用研究较少。因此，我们从心脏外科的角度对其进行了研究。
方法
24头猪进行体外循环，随机分为3组：对照组(主动脉阻断后仅给予停搏液；停跳30min后再灌流60min)；低剂量组(停搏液+ANP 25 mg)；高剂量组(停搏液+ANP 100 mg)。测定血和心肌cGMP、心肌钙和三磷酸腺苷浓度。用电子显微镜进行组织学检查。
结果
HANP治疗组大鼠血、心肌cGMP和心肌ATP水平均显著高于对照组。HANP治疗组心肌钙浓度明显低于对照组。在电子显微镜下，hANP治疗组很少观察到缺血再灌注损伤。
结论
研究表明，hANP改善了缺血再灌注损伤，并提示hANP对心脏手术(体外循环期间心脏停搏)相关的心肌损伤具有直接的心肌保护作用。
BACKGROUND
In recent years, various beneficial roles of human atrial natriuretic peptide (hANP) have been demonstrated in the internal medicine and surgical fields. However, direct myocardial protection by hANP against myocardial ischemic reperfusion injury has been rarely investigated. Thus, we investigated it from aspects of cardiac surgery.
METHODS
Twenty-four pigs underwent extracorporeal circulation and were divided into three groups: control group (treated with only cardioplegic solution after aorta clamping; cardioplegic arrest for 30 minutes followed by reperfusion for 60 minutes); low dose group (treated with cardioplegic solution and ANP (25 microg)); and high dose group (treated with cardioplegic solution and ANP (100 microg)). Blood and myocardial cGMP, myocardial Ca and ATP concentration were determined. Histological examinations were performed using an electron microscope.
RESULTS
Blood and myocardial cGMP and myocardial ATP levels were significantly higher in the hANP treatment groups than the control group. Myocardial Ca concentrations were significantly lower in the hANP treatment groups than the control group. In electron microscopy, ischemic reperfusion injury was rarely observed in the hANP treatment groups.
CONCLUSION
The study demonstrated that hANP improves ischemic reperfusion injury and suggested that hANP exerts direct myocardial protection against myocardial injury associated with cardiac surgery (cardioplegic arrest while cardiopulmonary bypass).
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心房钠尿因子引起内皮依赖性松弛并激活血管平滑肌中的颗粒鸟苷酸环化酶。
DOI：
10.1073/pnas.81.23.7661
发表时间：
1984
影响因子：
11.1
作者：
Winquist,RJ;Faison,EP;Waldman,SA;Schwartz,K;Murad,F;Rapoport,RM
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DOI：
10.1056/nejm198511213132106
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
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作者：
Laragh,JH
通讯作者：
Laragh,JH
一种准确、无创伤的超声方法，用于监测接受心脏手术的患者的心肌壁增厚情况。
影响因子：
24
作者：
Bolli,R;Hartley,CJ;Chelly,JE;Patel,BS;Rabinovitz,RS;Jeroudi,MO;Roberts,R;Noon,G
通讯作者：
Noon,G
影响因子：
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通讯作者：
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