Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics.
Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics.
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DOI：
10.3390/molecules20046866
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发表时间：
2015-04-16
期刊：
影响因子：
--
通讯作者：
Bruno JG
中科院分区：
文献类型：
--
作者：
Bruno JG
尽管核酸适体在诊断学和治疗学领域中因其易于体外开发、缺乏免疫原性和其他所需性质而具有巨大前景，但在临床或其他市场中几乎没有真正成功的基于适体的产品。这些商业缺陷的核心原因可能源于对抗体的工业承诺，包括对人源化单克隆抗体的巨大财政投资以及研究和开发界对适体及其性能的普遍无知。鉴于一些强有力的商业努力获得政府批准并将基于适体的产品推向市场的早期失败，似乎适体注定要永远让位于抗体。然而，适体相对于抗体的关键优势加上只有适体才能满足的利基市场需求，以及最近发表的数据仍然表明适体在传染病和癌症诊断和治疗等领域具有光明的商业前景。随着越来越多的研究人员和企业家熟悉适体，适体似乎不可避免地至少会被考虑在诊断和治疗中发挥更大的作用。这篇综述还研究了新的适体修饰，并试图预测新的适体应用，可能会在未来彻底改变生物医学技术，并导致上市产品。
Despite the great promise of nucleic acid aptamers in the areas of diagnostics and therapeutics for their facile in vitro development, lack of immunogenicity and other desirable properties, few truly successful aptamer-based products exist in the clinical or other markets. Core reasons for these commercial deficiencies probably stem from industrial commitment to antibodies including a huge financial investment in humanized monoclonal antibodies and a general ignorance about aptamers and their performance among the research and development community. Given the early failures of some strong commercial efforts to gain government approval and bring aptamer-based products to market, it may seem that aptamers are doomed to take a backseat to antibodies forever. However, the key advantages of aptamers over antibodies coupled with niche market needs that only aptamers can fill and more recent published data still point to a bright commercial future for aptamers in areas such as infectious disease and cancer diagnostics and therapeutics. As more researchers and entrepreneurs become familiar with aptamers, it seems inevitable that aptamers will at least be considered for expanded roles in diagnostics and therapeutics. This review also examines new aptamer modifications and attempts to predict new aptamer applications that could revolutionize biomedical technology in the future and lead to marketed products.
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影响因子：
3.7
作者：
Ahmad KM;Oh SS;Kim S;McClellen FM;Xiao Y;Soh HT
通讯作者：
Soh HT
DOI：
10.1006/bbrc.1997.6517
发表时间：
1997-05-08
影响因子：
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作者：
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作者：
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