Simulations of saccade curvature by models that place superior colliculus upstream from the local feedback loop.
Simulations of saccade curvature by models that place superior colliculus upstream from the local feedback loop.
复制标题
通过将上丘置于局部反馈回路上游的模型来模拟眼跳曲率。
DOI：
10.1152/jn.01199.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Gandhi,NeerajJ
中科院分区：
文献类型：
--
作者：
Walton,MarkMG;Sparks,DavidL;Gandhi,NeerajJ
当人类或猴子被要求对伴随着一个或多个干扰物的视觉目标进行扫视时，扫视的二维轨迹有时会显示出显著的曲率。Port和Wurtz使用双电极记录表明，这种现象与上级丘（SC）中多个部位的活动有关。曲率的时间和初始方向可以通过计算两个神经元的归一化活动的加权向量平均来预测。然而，正如这些作者所指出的，这种方法并不能正确预测弯曲扫视的最终方向。我们表明，这些运动的最终方向可以预测考虑到脑干扫视发生器和本地反馈回路。如果SC的输出被计算为激活部位所请求的扫视的加权向量平均值，并且该丘输出被下游结构解释为期望的位移，则将SC置于局部反馈回路上游的现有模型可以生成真实的扫视轨迹，包括最终方向。我们提出，扫视曲率是在两个站点，脑干扫视发生器解释为所需位移的变化的相对水平的活动的变化的结果。
When humans or monkeys are asked to make saccades to visual targets accompanied by one or more distractors, the two dimensional trajectory of the saccade will sometimes display significant curvature. Port and Wurtz used dual electrode recordings to show that this phenomenon is associated with activity at more than one site in superior colliculus (SC). The timing and initial direction of the curvature could be predicted by computing a weighted vector average of the normalized activity of the two neurons. As these authors noted, however, this approach does not result in correct predictions of the final direction of curved saccades. We show that the final direction of these movements can be predicted by taking into account the brain stem saccade generator and the local feedback loop. If the output of SC is computed as a weighted vector average of the saccades requested by the activated sites, and this collicular output is interpreted by downstream structures as desired displacement, existing models that place SC upstream from the local feedback loop can generate realistic saccade trajectories, including the final direction. We propose that saccade curvature is the result of a change in the relative level of activity at the two sites, which the brain stem saccade generator interprets as a change in desired displacement.
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影响因子：
1.9
作者：
D. Tweed;T. Vilis
通讯作者：
T. Vilis
影响因子：
2.5
作者：
Goossens, HHLM;Van Opstal, AJ
通讯作者：
Van Opstal, AJ
影响因子：
2.5
作者：
Port, NL;Wurtz, RH
通讯作者：
Wurtz, RH
有证据表明上丘参与眼球扫视运动的反馈控制。
DOI：
10.1152/jn.00886.2000
发表时间：
2002
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Soetedjo,Robijanto;Kaneko,ChrisRS;Fuchs,AlbertF
通讯作者：
Fuchs,AlbertF
DOI：
10.1098/rstb.2002.1098
发表时间：
2002-08-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Schall, JD
通讯作者：
Schall, JD