A clinical analysis of oropharyngeal squamous cell carcinoma: a single-institution’s experience
A clinical analysis of oropharyngeal squamous cell carcinoma: a single-institution’s experience
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口咽鳞状细胞癌的临床分析：单机构经验
DOI：
10.1007/s00405-021-07236-z
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发表时间：
2022
影响因子：
2.6
通讯作者：
Nakagawa Takashi
中科院分区：
文献类型：
--
作者：
Jiromaru Rina;Yasumatsu Ryuji;Yamamoto Hidetaka;Kuga Ryosuke;Hongo Takahiro;Nakano Takafumi;Manako Tomomi;Hashimoto Kazuki;Wakasaki Takahiro;Matsuo Mioko;Nakagawa Takashi
目的报道九州大学附属医院口咽鳞状细胞癌(OPSCC)的治疗结果、OPSCC病例总数及人乳头瘤病毒(HPV)相关癌比例随时间的变化。结果男性197例(82.1%)，女性40例(17.9%)。在长达十年的研究期间，疾病特异性、无进展和总生存率(OS)分别为69%、62%和61%。P16免疫组织化学阳性114例(48.1%)，高危型HPV mRNA原位杂交阳性105例(44.3%)。根据一项年度分析，与HPV相关的OPSCC病例数量增加。HPV阳性患者的预后明显好于HPV−患者。此外，p16+/HPV−患者的预后明显差于p16+/HPV+患者(OS：P= 0.0484)。HPV+OPSCC病例与年龄较小(<； 60岁)(p= 0.0429)、非吸烟者(p= 0.0001)、肿瘤侧方(<； 0.00001)、淋巴转移(<； 0.0001)和临床分期低(<； 0.0001)有关。结论日本和世界范围内与HPV相关的OPSCC病例呈上升趋势，且具有不吸烟习惯、年龄小、预后好等特点。即使在p16+鳞状细胞癌中，HPVHPV−的预后也很差，提示准确检测HPV值的重要性。为了确定HPV相关性和非相关性OPSCC的治疗强度，有必要积累病例，以便准确地检测HPV并比较治疗效果。
PurposeWe herein report the treatment outcome of oropharyngeal squamous cell carcinoma (OPSCC) at Kyushu University Hospital, the total number of OPSCC cases, and changes in the proportion of human papilloma virus (HPV)-related carcinomas over time.MethodWe performed a retrospective analysis of 237 cases treated for OPSCC at Kyushu University Hospital between 2013 and 2019. We performed HPV-mRNA in situ hybridization and p16 immunohistochemistry.ResultThis study included 197 males (82.1%) and 40 females (17.9%). The disease-specific, progression-free and overall survival (OS) were 69%, 62% and 61%, respectively, over the decade-long study period. p16-Immunohistochemistory and highrisk HPV mRNA in situ hybridization were positive in 114 (48.1%) and 105 (44.3%) cases, respectively. The number of HPV-related OPSCC cases increased according to an annual analysis. HPV+cases had a significantly better prognosis than HPV−cases. In addition, p16+/HPV−cases had a significantly worse prognosis than p16+/HPV+cases (OS:p= 0.0484). HPV+OPSCC cases were associated with a younger age (< 60 years old) (p= 0.0429), non-smoker (p= 0.0001), lateral tumor site (< 0.00001), lymphoid metastasis (< 0.0001) and low clinical stage (< 0.0001).ConclusionThe frequency of HPV-related OPSCC cases is increasing in Japan as well as worldwide, and such cases are characterized by no smoking habit, a young age, and a good prognosis. Even in p16+OPSCC, HPV−cases had a poor prognosis, suggesting the importance of accurate HPV determination. To determine the intensity of treatment for HPV-related and non-related OPSCC, it is necessary to accumulate cases for the accurate HPV determination and comparison of treatment effects.
影响因子：
4.8
作者：
Pytynia, Kristen B.;Dahlstrom, Kristina R.;Sturgis, Erich M.
通讯作者：
Sturgis, Erich M.
p16 和 HPV mRNA 结果不一致的口咽鳞状细胞癌
影响因子：
5.6
作者：
J. Shinn;Seth J. Davis;Krystle A. Lang;S. Rohde;Xiao;Ping Liu;W. Dupont;D. Plummer;W. Thorstad;R. Chernock;M. Mehrad;J. Lewis
通讯作者：
J. Lewis
影响因子：
4.6
作者：
Lewis, James S., Jr.;Beadle, Beth;Faquin, William C.
通讯作者：
Faquin, William C.