Epidemiology of HPV-associated oropharyngeal cancer.

Epidemiology of HPV-associated oropharyngeal cancer.
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DOI:
10.1016/j.oraloncology.2013.12.019
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发表时间:
2014-05
期刊:
影响因子:
4.8
通讯作者:
Sturgis, Erich M.
Sturgis, Erich M.
中科院分区:
医学2区
文献类型:
--
作者:
Pytynia, Kristen B.;Dahlstrom, Kristina R.;Sturgis, Erich M.

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口咽鳞状细胞癌的发病率呈上升趋势。这种特定部位发病率的增加是由于与人乳头瘤病毒(HPV)相关的鳞状细胞癌的增加,而与烟草相关的鳞状细胞癌的发病率正在下降。特别是,HPV相关性口咽鳞状细胞癌(OPSCC)在中年白人男性中的发病率增加,性行为是一个危险因素。人乳头瘤病毒相关的口咽鳞状细胞癌是一种病因学上越来越不同的头颈部癌症,具有独特的流行病学、临床和分子特征,与人乳头瘤病毒无关的癌症不同。在这篇综述中,我们讨论了HPV相关性OPSCC的流行病学,口腔/口咽部HPV感染的流行率,以及旨在减少HPV相关性OPSCC发病率的努力。
Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.
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