The Saccadic Re-Centering Bias is Associated with Activity Changes in the Human Superior Colliculus.
The Saccadic Re-Centering Bias is Associated with Activity Changes in the Human Superior Colliculus.
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DOI：
10.3389/fnhum.2010.00193
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发表时间：
2010
影响因子：
2.9
通讯作者：
Woldorff MG
中科院分区：
文献类型：
--
作者：
Krebs RM;Schoenfeld MA;Boehler CN;Song AW;Woldorff MG
能够有效地探索我们的视觉世界是至关重要的，有人认为直视（主要位置）可能在这种情况下起着特殊的作用。我们在人类中使用功能磁共振成像来研究相对于这种假定的默认位置，神经活动是如何被调节的。利用内源性线索范式，系统地操纵眼跳方向和眼跳起始位置，从而产生在振幅、方向可预测性和眼跳起始位置上匹配的朝主要位置（向心）和远离主要位置（离心）的眼跳。与早期的研究一致，我们发现在所有的扫视条件下，上丘（SC）、额叶视野和顶叶内沟的fMRI活动在扫视方向的对侧增强。此外，相对于离心性扫视，SC在重新定心时表现出相对的活性降低，这种模式与快速扫视反应时间相一致。相比之下，与其他类型的扫视相比，在重新定心的扫视过程中，皮层视野内的活动没有明显的调节，这表明重新定心的偏见主要是在皮层下而不是皮层加工阶段实现的。这种调制可能反映了一种特殊的编码偏差，有助于将凝视返回到凝视空间中的默认位置，在这个位置上，视网膜定位和自我中心的参考框架是对齐的，可以有效地探索视觉世界。
Being able to effectively explore our visual world is of fundamental importance, and it has been suggested that the straight-ahead gaze (primary position) might play a special role in this context. We employed fMRI in humans to investigate how neural activity might be modulated for saccades relative to this putative default position. Using an endogenous cueing paradigm, saccade direction and orbital starting position were systematically manipulated, resulting in saccades toward primary position (centripetal) and away from primary position (centrifugal) that were matched in amplitude, directional predictability, as well as orbital starting position. In accord with earlier research, we found that fMRI activity in the superior colliculus (SC), as well as in the frontal eye fields and the intraparietal sulcus, was enhanced contralateral to saccade direction across all saccade conditions. Furthermore, the SC exhibited a relative activity decrease during re-centering relative to centrifugal saccades, a pattern that was paralleled by faster saccadic reaction times. In contrast, activity within the cortical eye fields was not significantly modulated during re-centering saccades as compared to other saccade types, suggesting that the re-centering bias is predominantly implemented at a subcortical rather than cortical processing stage. Such a modulation might reflect a special coding bias facilitating the return of gaze to a default position in the gaze space in which retinotopic and egocentric reference frames are aligned and from which the visual world can be effectively explored.
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