Obesity and vulnerability of the CNS.
Obesity and vulnerability of the CNS.
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DOI：
10.1016/j.bbadis.2008.10.004
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发表时间：
2009-05
影响因子：
6.2
通讯作者：
Morrison, Christopher D.
中科院分区：
文献类型：
--
作者：
Bruce-Keller, Annadora J.;Keller, Jeffrey N.;Morrison, Christopher D.
肥胖的发病率在世界范围内呈上升趋势，在西方发达国家尤为明显。虽然肥胖对代谢和心血管生理的影响已经得到了很好的证实，但流行病学和实验数据开始证实，中枢神经系统（CNS）也可能受到肥胖和肥胖引起的代谢功能障碍的不利影响。具体而言，数据显示，人群中的肥胖与认知能力下降和对脑损伤的易感性增加有关，而动物模型的实验研究证实了易感性增加和认知功能下降的情况。这篇综述将描述人类和动物研究的发现，以总结目前对肥胖如何影响大脑的理解。此外，将讨论旨在确定体脑对话关键要素的研究，以评估各种代谢和脂肪相关信号如何对中枢神经系统产生不利影响。总的来说，数据表明，肥胖引起的代谢改变可能与年龄显著协同作用，损害脑功能，加速与年龄相关的神经系统疾病。因此，随着越来越多的肥胖个体接近老年，加强对肥胖和肥胖相关代谢功能障碍对大脑的影响的理解尤为重要。
The incidence of obesity is increasing worldwide, and is especially pronounced in developed western countries. While the consequences of obesity on metabolic and cardiovascular physiology are well established, epidemiological and experimental data are beginning to establish that the central nervous system (CNS) may also be detrimentally affected by obesity and obesity-induced metabolic dysfunction. In particular, data show that obesity in human populations is associated with cognitive decline and enhanced vulnerability to brain injury, while experimental studies in animal models confirm a profile of heightened vulnerability and decreased cognitive function. This review will describe findings from human and animal studies to summarize current understanding of how obesity affects the brain. Furthermore, studies aimed at identifying key elements of body-brain dialog will be discussed to assess how various metabolic and adipose-related signals could adversely affect the CNS. Overall, data suggest that obesity-induced alterations in metabolism may significantly synergize with age to impair brain function and accelerate age-related diseases of the nervous system. Thus, enhanced understanding of the effects of obesity and obesity-related metabolic dysfunction on the brain are especially critical as increasing numbers of obese individuals approach advanced age.
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影响因子：
7.7
作者：
Boden, G;She, PX;Ruderman, N
通讯作者：
Ruderman, N
影响因子：
4.2
作者：
Elias, MF;Elias, PK;D'Agostino, RB
通讯作者：
D'Agostino, RB
影响因子：
7.4
作者：
Choi, JY;Jang, EH;Kang, JH
通讯作者：
Kang, JH
DOI：
10.1097/01.ta.0000200842.19740.38
发表时间：
2006-09-01
影响因子：
--
作者：
Brown, Carlos V. R.;Rhee, Peter;Demetriades, Demetrios
通讯作者：
Demetriades, Demetrios
影响因子：
7.7
作者：
Banks, WA;Coon, AB;Morley, JE
通讯作者：
Morley, JE