Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.
Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.
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实体瘤中T型钙通道基因特征的预后相关性：准备临床验证的相关性。
DOI：
10.1371/journal.pone.0182818
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Bootman MD
中科院分区：
文献类型：
--
作者：
Fornaro L;Vivaldi C;Lin D;Xue H;Falcone A;Wang Y;Crea F;Bootman MD
T型钙通道（TTCC）介导钙离子跨膜内流。TTCC调节许多生理过程，包括心脏起搏和神经元活动。此外，它们与肿瘤组织的增殖、迁移和分化有关。虽然TTCC介导的钙离子内流下游的信号传导事件尚未完全阐明，但很明显，TTCC表达的变化促进肿瘤形成并阻碍对治疗的反应。我们通过一个公开的数据库研究了TTCC基因（所有三种亚型; CACNA-1G，CACNA-1H和CACNA-1 I）的表达及其在三种主要实体瘤（即胃癌，肺癌和卵巢癌）中的预后价值。在胃癌中，所有CACNA基因的表达与I-IV期患者的总生存期（OS）相关（所有p<0.05）。通过结合三种潜在的生物标志物，开发了TTCC特征，其在IV期和I-III期患者中均与OS保持显著相关。在肺癌和卵巢癌中，当考虑所有肿瘤分期时，与OS的相关性也很显著，但在将病例分为局部和转移性子集后，部分丢失或不确定。CACNA基因表达的改变与肿瘤预后有关。胃癌代表了最有希望的进一步评估的设置。
T-type calcium channels (TTCCs) mediate calcium influx across the cell membrane. TTCCs regulate numerous physiological processes including cardiac pacemaking and neuronal activity. In addition, they have been implicated in the proliferation, migration and differentiation of tumour tissues. Although the signalling events downstream of TTCC-mediated calcium influx are not fully elucidated, it is clear that variations in the expression of TTCCs promote tumour formation and hinder response to treatment. We examined the expression of TTCC genes (all three subtypes; CACNA-1G, CACNA-1H and CACNA-1I) and their prognostic value in three major solid tumours (i.e. gastric, lung and ovarian cancers) via a publicly accessible database. In gastric cancer, expression of all the CACNA genes was associated with overall survival (OS) among stage I-IV patients (all p<0.05). By combining the three potential biomarkers, a TTCC signature was developed, which retained a significant association with OS both in stage IV and stage I-III patients. In lung and ovarian cancer, association with OS was also significant when all tumour stages were considered, but was partly lost or inconclusive after splitting cases into localized and metastatic subsets. Alterations in CACNA gene expression are linked to tumour prognosis. Gastric cancer represents the most promising setting for further evaluation.
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DOI：
10.1007/s00249-016-1144-z
发表时间：
2016-10
影响因子：
2
作者：
Buchanan, Paul J.;McCloskey, Karen D.
通讯作者：
McCloskey, Karen D.
影响因子：
5.2
作者：
Dziegielewska, Barbara;Brautigan, David L.;Dziegielewski, Jaroslaw
通讯作者：
Dziegielewski, Jaroslaw
影响因子：
4
作者：
Lu, Fengmin;Chen, Hairu;Wu, Songwei
通讯作者：
Wu, Songwei
影响因子：
4.7
作者：
Press, Joshua Z.;Kenyon, Jennifer A.;Wang, Y. Z.
通讯作者：
Wang, Y. Z.
影响因子：
2.4
作者：
Li, Wei;Zhang, Shu-Lan;Li, Ming
通讯作者：
Li, Ming