Individual response to electroconvulsive therapy is not correlated between multiple treatment courses.
Individual response to electroconvulsive therapy is not correlated between multiple treatment courses.
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DOI：
10.1016/j.jad.2021.11.002
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发表时间：
2022-02-01
影响因子：
6.6
通讯作者：
Luccarelli J
中科院分区：
文献类型：
--
作者：
Hart KL;Henry ME;McCoy TH;Seiner SJ;Luccarelli J
电休克疗法（ECT）有效地治疗抑郁症，但许多患者随后会复发。虽然一些指南建议先前对ECT的反应是后续情绪发作中ECT的指示，但尚不清楚ECT的反应是否与治疗过程相关。本研究探讨了第一次治疗时对ECT的反应是否与第二次独立ECT疗程中对治疗的反应相关。在2011年至2020年期间接受两种不同ECT治疗疗程的患者的单中心回顾性队列，这些患者在基线和治疗#5后使用抑郁症状快速量表（QIDS）自我报告抑郁症状。286例患者在研究期间接受了两个独立的ECT系列，其中153例在两个系列中接受了至少5次治疗。患者在每个治疗系列开始时的QIDS评分相似（Pearson相关性，r = 0.58，p <0.001），但5次ECT治疗后QIDS的变化在个体患者的系列之间不相关（Pearson相关性，r = 0.083，p = 0.31）。在多变量分析中，两个治疗系列的QIDS变化相似，但患者不太可能在第二个治疗系列中接受5种治疗。回顾性队列不能控制影响重复ECT治疗的因素。虽然在两个独立的疗程后，平均最终QIDS评分相同，但对于个体患者，治疗系列之间抑郁症状的变化不相关。需要进一步的研究来确定可能预测纵向ECT反应的因素。
Electroconvulsive therapy (ECT) effectively treats depressive disorders, but many patients will have subsequent relapses. While some guidelines suggest prior response to ECT is an indication for ECT in a subsequent mood episode, it is unknown whether response to ECT is correlated between treatment courses. This study explores whether response to ECT at a first treatment correlates with response to treatment in a second independent ECT course. Single-center retrospective cohort of patients receiving two different ECT treatment courses between 2011 and 2020 and who self-reported depression symptoms using the Quick Inventory of Depressive Symptomatology (QIDS) at baseline and following treatment #5. 286 patients received two independent ECT series during the study period, of whom 153 received at least 5 treatments in both series. Patients had similar QIDS scores at the start of each treatment series (Pearson’s correlation, r = 0.58, p <0.001), but the change in QIDS following 5 ECT treatments was not correlated between series for individual patients (Pearson’s correlation, r = 0.083, p = 0.31). In multivariate analyses, change in QIDS was similar for both treatment series, but patients were less likely to receive 5 treatments in the second treatment series. retrospective cohort cannot control for factors influencing access to repeat ECT treatment While on average final QIDS score was the same following two independent treatment courses, for individual patients the change in depression symptoms was not correlated between treatment series. Further research is needed to identify factors that may predict longitudinal ECT response.
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影响因子：
3.1
作者：
Leiknes, Kari Ann;Jarosh-von Schweder, Lindy;Hoie, Bjorg
通讯作者：
Hoie, Bjorg
影响因子：
10.6
作者：
Prudic, J;Olfson, M;Sackeim, HA
通讯作者：
Sackeim, HA
影响因子：
6.6
作者：
SACCUZZO, DP;BRAFF, DL
通讯作者：
BRAFF, DL
DOI：
10.1016/s2215-0366(17)30077-9
发表时间：
2017-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Anderson IM;Blamire A;Branton T;Clark R;Downey D;Dunn G;Easton A;Elliott R;Elwell C;Hayden K;Holland F;Karim S;Loo C;Lowe J;Nair R;Oakley T;Prakash A;Sharma PK;Williams SR;McAllister-Williams RH;Ketamine-ECT Study team
通讯作者：
Ketamine-ECT Study team
影响因子：
6.7
作者：
Eichler HG;Pignatti F;Schwarzer-Daum B;Hidalgo-Simon A;Eichler I;Arlett P;Humphreys A;Vamvakas S;Brun N;Rasi G
通讯作者：
Rasi G