Coagulation and autoimmunity in scleroderma interstitial lung disease.
Coagulation and autoimmunity in scleroderma interstitial lung disease.
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DOI：
10.1016/j.semarthrit.2010.10.002
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发表时间：
2011-10
影响因子：
5
通讯作者：
Bogatkevich GS
中科院分区：
文献类型：
--
作者：
Ludwicka-Bradley A;Silver RM;Bogatkevich GS
Interstitial lung disease in systemic sclerosis (SSc-ILD) is often an irreversible and progressive fibrosing process that now is the leading cause of scleroderma-related deaths. In this review we present our current understanding of the role played by coagulation and particularly by thrombin in autoimmune-mediated tissue injury and fibrosis, mainly as it relates to SSc-ILD. We used PubMed to search for articles published up to October 2010 for keywords referring to autoimmunity, coagulation, pulmonary fibrosis, and scleroderma. SSc-ILD is an autoimmune disease associated with lymphocyte activation and release of various cytokines and growth factors. The production of autoantibodies is a central feature in SSc. Activation of the coagulation cascade with release of thrombin is 1 of the earliest events following tissue injury. Thrombin contributes to autoimmune responses by activating of pathogenic Th2 lymphocyte profile in SSc. Thrombin also modulates tissue repair responses, stimulates transformation of epithelial cells, endothelial cells, and fibroblasts into myofibroblast phenotype, and induces secretion of several pro-immune and profibrotic factors, which serve as antigens for pathogenic autoantibodies production in SSc-ILD. The identification of links between autoimmunity and coagulation would provide new insights into the pathogenesis of pulmonary fibrosis associated with autoimmune diseases and further acknowledge the importance of thrombin in the development of SSc-ILD.
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DOI：
10.1513/pats.200602-021tk
发表时间：
2006-06-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Ask, Kjetil;Martin, Gail E M;Gauldie, Jack
通讯作者：
Gauldie, Jack
影响因子：
64.8
作者：
Coughlin, SR
通讯作者：
Coughlin, SR
影响因子：
27.4
作者：
Balada, E.;Simeon-Aznar, C. P.;Vilardell-Tarres, M.
通讯作者：
Vilardell-Tarres, M.
影响因子：
3.1
作者：
Arciniegas, E;Neves, CY;Cardier, JE
通讯作者：
Cardier, JE
DOI：
10.1084/jem.20041393
发表时间：
2005-03-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Abdollahi A;Li M;Ping G;Plathow C;Domhan S;Kiessling F;Lee LB;McMahon G;Gröne HJ;Lipson KE;Huber PE
通讯作者：
Huber PE