Effect of PMMA cement radical polymerisation on the inflammatory response
Effect of PMMA cement radical polymerisation on the inflammatory response
复制标题
PMMA水泥自由基聚合对炎症反应的影响
DOI：
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复制
发表时间：
2004
期刊：
影响因子：
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通讯作者：
L. Ambrosio
中科院分区：
文献类型：
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作者：
M. Santin;A. Motta;Assunta Borzachiello;L. Nicolais;L. Ambrosio
The effect of the radical polymerisation taking place during the hardening of the polymethyl methacrylate (PMMA) bone cements is known to cause bone necrosis through the relatively high exothermic reaction and the leaching of toxic non reacted monomers. The inflammatory response towards this class of cements has also been shown and ascribed mainly to the phagocytosis of the material particles. However, the effect of the radical polymerisation on the adsorption of plasma proteins and on the activation of monocytes/macrophages when the material is in a non-phagocytosable dimension has not been elucidated.In the present work, the polymerisation of three bone cements, CMW-1, Palavit and Simplex-P in a clinically reflective environment and its effect on the formation of a surface conditioning film as well as on the inflammatory cell activation were investigated.The data showed that on CMWand Simplex-P the polymerisation was not fully accomplished. CMW released high levels of non-reacted monomers, no significant macrophage adhesion and high oxidative burst and cytokine production. The relatively lower levels of released monomers in Simplex and Palavit seemed to promote a lower inflammatory response while cell adhesion was favoured by patches of plasma components entrapped in the hardening dough during the polymerisation.
生物医学聚合物的蛋白质吸附影响活化的单核细胞产生成纤维细胞刺激因子。
DOI：
10.1002/jbm.820260404
发表时间：
1992
期刊：
Journal of biomedical materials research
影响因子：
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作者：
Bonfield,TL;Colton,E;Anderson,JM
通讯作者：
Anderson,JM