Interleukin-24 inhibits the phenotype and tumorigenicity of cancer stem cell in osteosarcoma via downregulation Notch and Wnt/β-catenin signaling.
Interleukin-24 inhibits the phenotype and tumorigenicity of cancer stem cell in osteosarcoma via downregulation Notch and Wnt/β-catenin signaling.
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DOI：
10.1016/j.jbo.2021.100403
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发表时间：
2021-12
影响因子：
3.4
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Zhuo B;Wang X;Shen Y;Li J;Li S;Li Y;Wang R
IL-24可降低CD133+骨肉瘤CSCs中干细胞标志物的表达。IL-24可抑制CD133+骨肉瘤CSCs的成瘤和进一步发展。IL-24通过抑制Notch和Wnt/β-Catenin信号通路抑制骨肉瘤CSCs的致瘤性。骨肉瘤经常表现为复发和转移，即使原发灶被根除和/或进行了放疗和化疗。骨肉瘤肿瘤干细胞(CSCs)是骨肉瘤复发转移的关键因素之一。我们已经证明白介素24(IL-24)在体外可以抑制骨肉瘤细胞的增殖、迁移和侵袭。在本研究中，我们研究了IL-24在抑制骨肉瘤CSCs生长中的作用。IL-24在体外可抑制骨肉瘤CSCs的增殖和侵袭，降低干细胞的干性。在裸鼠异种移植模型中，IL-24显著抑制骨肉瘤CSCs来源的肿瘤生长。此外，我们还发现IL-24能够使Notch和Wnt/β-catenin信号失活，这对CSCs的生物学特性的发展具有重要意义。这些数据表明，IL-24不仅能杀死骨肉瘤中的癌细胞，还能杀死CSCs，这表明IL-24可能会根除骨肉瘤，提高骨肉瘤患者的长期治愈率。
IL-24 can decrease the expression of stem cell markers in CD133+ osteosarcoma CSCs. IL-24 can inhibit CD133+ osteosarcoma CSCs to form tumors and develop further. IL-24 inhibits tumorigenicity of osteosarcoma CSCs via inhibiting Notch and Wnt/β-Catenin Signaling. Osteosarcoma frequently presents as recurrence and metastasis, even if the primary lesion was eradicated and/or radiotherapy and chemotherapy were administered. Osteosarcoma cancer stem cells (CSCs) are one of the key factors for the recurrence and metastasis of osteosarcoma. We have shown that interleukin-24 (IL-24) inhibits osteosarcoma cell proliferation, migration and invasion in vitro. In the current study, we investigated the role of IL-24 in inhibiting the growth of osteosarcoma CSCs. IL-24 inhibited proliferation and invasion and decreased the stemness of osteosarcoma CSCs in vitro. In a nude mouse xenograft model, IL-24 significantly inhibited the growth of tumors originating from osteosarcoma CSCs. Moreover, we found that IL-24 was able to inactivate both Notch and Wnt/β-Catenin signaling, which are important for the development of the biological characteristics of CSCs. These data demonstrate that IL-24 is able to kill not only cancer cells but also CSCs in osteosarcoma, suggesting that IL-24 might eradicate osteosarcoma and enhance long-term cure rates in patients with osteosarcoma.
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影响因子：
2.2
作者：
Wilson, H.;Huelsmeyer, M.;Argyle, D. J.
通讯作者：
Argyle, D. J.
影响因子：
5.2
作者：
Fujii, Hiromasa;Honoki, Kanya;Takakura, Yoshinori
通讯作者：
Takakura, Yoshinori
影响因子：
11.2
作者：
Song, Siyuan;Christova, Tania;Attisano, Liliana
通讯作者：
Attisano, Liliana
影响因子：
3.8
作者：
Martins-Neves SR;Lopes ÁO;do Carmo A;Paiva AA;Simões PC;Abrunhosa AJ;Gomes CM
通讯作者：
Gomes CM
DOI：
10.1073/pnas.0804089105
发表时间：
2008-07-15
影响因子：
11.1
作者：
Sauane, Moira;Su, Zao-Zhong;Fisher, Paul B.
通讯作者：
Fisher, Paul B.