The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual.
The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual.
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DOI：
10.1152/jn.00561.2020
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发表时间：
2021-02-01
影响因子：
2.5
通讯作者：
Yeo BTT
中科院分区：
文献类型：
--
作者：
Xue A;Kong R;Yang Q;Eldaief MC;Angeli PA;DiNicola LM;Braga RM;Buckner RL;Yeo BTT
小脑的不同区域连接到大脑皮层的不同区域，形成复杂的地形。虽然小脑组织已被检查组平均数据，个人的研究提供了一个机会，发现出现在一个更高的空间分辨率的功能。在这里，功能连接MRI被用来检查两个集中采样的个体的小脑（每个扫描31次）。与躯体运动皮层的连接显示了预期的身体地图的交叉偏侧性和地形。一个令人惊讶的发现是连接到初级视觉皮层沿着蚓部与证据的代表性的中央领域。在大脑半球内，每个人都表现出从倒置的前叶躯体运动图到高阶关联区的分层进展。层次结构在第I/II脚结束，然后以相反的顺序进行，直到后叶的直立躯体运动图。第三组网络的证据是在小脑的最后部分发现的。对高阶关联网络的详细分析揭示了与默认网络相关的两个不同网络的鲁棒表示，与认知控制相关的多个网络，以及语言网络的单独表示。虽然个体之间出现了特殊的空间细节，但每个网络都可以在两个个体中检测到，并且放置在小脑内的种子区域概括了空间特异性大脑网络的全部范围。在第一/第二脚顶点的并列区域中观察到的多个网络证实了该区域对高阶认知功能的重要性，并揭示了新的组织细节。新的值得注意的是，小脑组织的稳定的、个体内的地图揭示了大脑皮层的有序宏观表征，其中局部并列区域代表不同的网络。此外，个体还表现出特殊的组织特征。
Distinct regions of the cerebellum connect to separate regions of the cerebral cortex forming a complex topography. Although cerebellar organization has been examined in group-averaged data, study of individuals provides an opportunity to discover features that emerge at a higher spatial resolution. Here, functional connectivity MRI was used to examine the cerebellum of two intensively sampled individuals (each scanned 31 times). Connectivity to somatomotor cortex showed the expected crossed laterality and topography of the body maps. A surprising discovery was connectivity to the primary visual cortex along the vermis with evidence for representation of the central field. Within the hemispheres, each individual displayed a hierarchical progression from the inverted anterior lobe somatomotor map through to higher-order association zones. The hierarchy ended at Crus I/II and then progressed in reverse order through to the upright somatomotor map in the posterior lobe. Evidence for a third set of networks was found in the most posterior extent of the cerebellum. Detailed analysis of the higher-order association networks revealed robust representations of two distinct networks linked to the default network, multiple networks linked to cognitive control, as well as a separate representation of a language network. Although idiosyncratic spatial details emerged between subjects, each network could be detected in both individuals, and seed regions placed within the cerebellum recapitulated the full extent of the spatially specific cerebral networks. The observation of multiple networks in juxtaposed regions at the Crus I/II apex confirms the importance of this zone to higher-order cognitive function and reveals new organizational details. NEW & NOTEWORTHY Stable, within-individual maps of cerebellar organization reveal orderly macroscale representations of the cerebral cortex with local juxtaposed zones representing distinct networks. In addition, individuals reveal idiosyncratic organizational features.
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