Automatically detecting bregma and lambda points in rodent skull anatomy images.
Automatically detecting bregma and lambda points in rodent skull anatomy images.
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DOI:
10.1371/journal.pone.0244378
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发表时间:
2020
期刊:
影响因子:
3.7
通讯作者:
Abbaszadeh S
中科院分区:
文献类型:
--
作者:
Zhou P;Liu Z;Wu H;Wang Y;Lei Y;Abbaszadeh S
Currently, injection sites of probes, cannula, and optic fibers in stereotactic neurosurgery are typically located manually. This step involves location estimations based on human experiences and thus introduces errors. In order to reduce localization error and improve repeatability of experiments and treatments, we investigate an automated method to locate injection sites. This paper proposes a localization framework, which integrates a region-based convolutional network and a fully convolutional network, to locate specific anatomical points on skulls of rodents. Experiment results show that the proposed localization framework is capable of identifying and locatin bregma and lambda in rodent skull anatomy images with mean errors less than 300 μm. This method is robust to different lighting conditions and mouse orientations, and has the potential to simplify the procedure of locating injection sites.
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影响因子:
4.6
作者:
Rangarajan JR;Vande Velde G;van Gent F;De Vloo P;Dresselaers T;Depypere M;van Kuyck K;Nuttin B;Himmelreich U;Maes F
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通讯作者:
Liang, Rongguang