Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila.
Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila.
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DOI：
10.1371/journal.pone.0011628
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发表时间：
2010-07-16
期刊：
影响因子：
3.7
通讯作者：
Holmes TC
中科院分区：
文献类型：
--
作者：
Sheeba V;Fogle KJ;Holmes TC
光激活的大腹侧时钟神经元（大LNv）调节果蝇的行为觉醒和睡眠，而它们的对应物小LNv（s-LNv）对昼夜节律行为很重要。最近，有人提出，昼夜自发行为活动的模式是由两个解剖学上不同的振荡器组成的早晨振荡器在小LNv和晚上振荡器在外侧背神经元和一个不确定的背起搏神经元的数量介导的。这与由不受解剖学约束的网络模型描述的回路形成对比。通过选择性地消融小LNv而保留大LNv，我们测试了小LNv和大LNv对于调节生活在标准光/暗周期中的动物的早晨行为的相对重要性。行为预期的早晨和高振幅的早晨惊吓反应，这与光的发病是一致的保留在小LNv功能消融的动物。然而，在从规则的光/暗周期到恒定黑暗的过渡期间，这些动物的早晨行为峰值的幅度严重衰减，进一步支持小LNv是昼夜节律行为所必需的。在没有功能性小LNv的情况下，大LNv与其他昼夜节律神经元的网络相结合足以用于早晨预期和高振幅光激活的早晨惊吓反应。
Light-activated large ventral lateral clock neurons (large LNv) modulate behavioral arousal and sleep in Drosophila while their counterparts, the small LNv (s-LNv) are important for circadian behavior. Recently, it has been proposed that the pattern of day-night locomotor behavioral activity is mediated by two anatomically distinct oscillators composed of a morning oscillator in the small LNv and an evening oscillator in the lateral dorsal neurons and an undefined number of dorsal pacemaker neurons. This contrasts with a circuit described by network models which are not as anatomically constrained. By selectively ablating the small LNv while sparing the large LNv, we tested the relative importance of the small and large LNv for regulating morning behavior of animals living in standard light/dark cycles. Behavioral anticipation of the onset of morning and the high amplitude morning startle response which coincides with light onset are preserved in small LNv functionally-ablated animals. However, the amplitude of the morning behavioral peak is severely attenuated in these animals during the transition from regular light/dark cycles to constant darkness, providing further support that small LNv are necessary for circadian behavior. The large LNv, in combination with the network of other circadian neurons, in the absence of functional small LNv are sufficient for the morning anticipation and the high amplitude light-activated morning startle response.
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影响因子：
9.8
作者：
Lear BC;Zhang L;Allada R
通讯作者：
Allada R
影响因子：
64.5
作者：
Nitabach, MN;Blau, J;Holmes, TC
通讯作者：
Holmes, TC
影响因子：
56.9
作者：
MICHEL, S;GEUSZ, ME;BLOCK, GD
通讯作者：
BLOCK, GD
影响因子：
5.3
作者：
Harrisingh, Marie C.;Wu, Ying;Nitabach, Michael N.
通讯作者：
Nitabach, Michael N.
DOI：
10.1007/s003590050192
发表时间：
1998-04-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
Helfrich-Förster, C
通讯作者：
Helfrich-Förster, C