Metabolic Engineering of Yeast for the Production of 3-Hydroxypropionic Acid.
Metabolic Engineering of Yeast for the Production of 3-Hydroxypropionic Acid.
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用于生产 3-羟基丙酸的酵母代谢工程
DOI：
10.3389/fmicb.2018.02185
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发表时间：
2018
影响因子：
5.2
通讯作者：
Ji XJ
中科院分区：
文献类型：
--
作者：
Ji RY;Ding Y;Shi TQ;Lin L;Huang H;Gao Z;Ji XJ
The beta-hydroxy acid 3-hydroxypropionic acid (3-HP) is an attractive platform compound that can be used as a precursor for many commercially interesting compounds. In order to reduce the dependence on petroleum and follow sustainable development, 3-HP has been produced biologically from glucose or glycerol. It is reported that 3-HP synthesis pathways can be constructed in microbes such as Escherichia coli, Klebsiella pneumoniae and the yeast Saccharomyces cerevisiae. Among these host strains, yeast is prominent because of its strong acid tolerance which can simplify the fermentation process. Currently, the malonyl-CoA reductase pathway and the β-alanine pathway have been successfully constructed in yeast. This review presents the current developments in 3-HP production using yeast as an industrial host. By combining genome-scale engineering tools, malonyl-CoA biosensors and optimization of downstream fermentation, the production of 3-HP in yeast has the potential to reach or even exceed the yield of chemical production in the future.
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影响因子：
6.4
作者：
Kildegaard KR;Jensen NB;Schneider K;Czarnotta E;Özdemir E;Klein T;Maury J;Ebert BE;Christensen HB;Chen Y;Kim IK;Herrgård MJ;Blank LM;Forster J;Nielsen J;Borodina I
通讯作者：
Borodina I
最大限度地减少工业乙醇酵母中的甘油合成而不影响其发酵性能
影响因子：
8.4
作者：
Guo, Zhong-peng;Zhang, Liang;Shi, Gui-yang
通讯作者：
Shi, Gui-yang
影响因子：
3.7
作者：
Kocharin K;Chen Y;Siewers V;Nielsen J
通讯作者：
Nielsen J
影响因子：
3.7
作者：
Chen Y;Siewers V;Nielsen J
通讯作者：
Nielsen J
影响因子：
4.7
作者：
David, Florian;Nielsen, Jens;Siewers, Verena
通讯作者：
Siewers, Verena