Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults.
Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults.
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DOI：
10.1001/jama.2013.613
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发表时间：
2013-02-20
影响因子：
120.7
通讯作者：
Doyle, William J.
中科院分区：
文献类型：
--
作者：
Cohen, Sheldon;Janicki-Deverts, Denise;Turner, Ronald B.;Casselbrant, Margaretha L.;Li-Korotky, Ha-Sheng;Epel, Elissa S.;Doyle, William J.
虽然白细胞端粒长度与死亡率和许多慢性疾病相关，这些疾病被认为是与年龄相关的功能下降的表现，但尚不清楚它是否与年轻健康人群中的急性疾病有关。确定白细胞中较短的端粒，特别是CD 8 CD 28 − T细胞，是否与年轻人至中年人对上呼吸道感染和临床疾病的抵抗力下降有关。在2008年至2011年期间，对宾夕法尼亚州匹兹堡市152名18至55岁健康居民的外周血单核细胞（PBMC）和T细胞亚群（CD 4，CD 8 CD 28+，CD 8 CD 28 −）中的端粒长度进行了评估。参与者随后被隔离（单间），给予含有普通感冒病毒（鼻病毒39）的滴鼻剂，并监测5天的感染和临床疾病的发展。感染（病毒脱落或病毒特异性抗体滴度增加4倍）和临床疾病（经证实的感染加上客观疾病体征）。感染和临床疾病的发生率分别为69%（n = 105）和22%（n = 33）。端粒越短，感染几率越大，与攻毒前病毒特异性抗体、人口统计学、避孕药使用、季节和体重指数无关（端粒长度每1-SD减少的PBMC比值比[OR]，1.71 [95% CI，1.08-2.72]; n = 128 [最短三分位数77%感染;中间，66%;最长，57%]; CD 4：OR，1.76 [95% CI，1.15-2.70]; n = 146 [最短三分位数80%感染;中间，71%;最长，54%]; CD 8 CD 28+：OR，1.93 [95% CI，1.21-3.09]，n = 132 [最短三分位数84%感染;中间，64%;最长，58%]; CD 8 CD 28-：OR，2.02 [95% CI，1.29-3.16]; n = 144 [最短三分位数77%感染;中间，75%;最长，50%]）。CD 8 CD 28 −是唯一一个端粒较短与临床疾病风险较高相关的细胞群体（OR，1.69 [95%CI，1.01-2.84]; n = 144 [最短三分位数，26%;中间，22%;最长，13%]）。CD 8 CD 28 −端粒长度与感染之间的相关性随着年龄的增长而增加（CD 8 CD 28 −端粒长度-X-年龄相互作用，B = 0.09 [95% CI，0.02-0.16]，P = 0.01，n = 144）。在这项针对18至55岁健康人群的初步研究中，较短的CD 8 CD 28-T细胞端粒长度与实验诱导的急性上呼吸道感染和临床疾病的风险增加有关。
Although leukocyte telomere length is associated with mortality and many chronic diseases thought to be manifestations of age-related functional decline, it is not known whether it relates to acute disease in younger healthy populations. To determine whether shorter telomeres in leukocytes, especially CD8CD28− T cells, are associated with decreased resistance to upper respiratory infection and clinical illness in young to midlife adults. Between 2008 and 2011, telomere length was assessed in peripheral blood mononuclear cells (PBMCs) and T-cell subsets (CD4, CD8CD28+, CD8CD28−) from 152 healthy 18- to 55-year-old residents of Pittsburgh, Pennsylvania. Participants were subsequently quarantined (single rooms), administered nasal drops containing a common cold virus (rhinovirus 39), and monitored for 5 days for development of infection and clinical illness. Infection (virus shedding or 4-fold increase in virus-specific antibody titer) and clinical illness (verified infection plus objective signs of illness). Rates of infections and clinical illness were 69% (n = 105) and 22% (n = 33), respectively. Shorter telomeres were associated with greater odds of infection, independent of prechallenge virus-specific antibody, demographics, contraceptive use, season, and body mass index (PBMC odds ratio [OR] per 1-SD decrease in telomere length, 1.71 [95% CI, 1.08–2.72]; n = 128 [shortest tertile 77% infected; middle, 66%; longest, 57%]; CD4: OR, 1.76 [95% CI, 1.15–2.70]; n = 146 [shortest tertile 80% infected; middle, 71%; longest, 54%]; CD8CD28+: OR, 1.93 [95% CI, 1.21–3.09], n = 132 [shortest tertile 84% infected; middle, 64%; longest, 58%]; CD8CD28-: OR, 2.02 [95% CI, 1.29–3.16]; n = 144 [shortest tertile 77% infected; middle, 75%; longest, 50%]). CD8CD28− was the only cell population in which shorter telomeres were associated with greater risk of clinical illness (OR, 1.69 [95% CI, 1.01–2.84]; n = 144 [shortest tertile, 26%; middle, 22%; longest, 13%]). The association between CD8CD28− telomere length and infection increased with age (CD8CD28− telomere length-X-age interaction, b = 0.09 [95% CI, 0.02–0.16], P = .01, n = 144). In this preliminary study among a cohort of healthy 18- to 55-year-olds, shorter CD8CD28− T-cell telomere length was associated with increased risk for experimentally induced acute upper respiratory infection and clinical illness.
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影响因子：
2.2
作者：
Lin, Jue;Epel, Elissa;Cheon, Joshua;Kroenke, Candyce;Sinclair, Elizabeth;Bigos, Marty;Wolkowitz, Owen;Mellon, Synthia;Blackburn, Elizabeth
通讯作者：
Blackburn, Elizabeth
影响因子：
9.1
作者：
Parish, Stanley T.;Wu, Jennifer E.;Effros, Rita B.
通讯作者：
Effros, Rita B.
影响因子：
3.8
作者：
Effros, RB;Allsopp, R;Giorgi, JV
通讯作者：
Giorgi, JV
影响因子：
7.7
作者：
Ehrlenbach, Silvia;Willeit, Peter;Brandstaetter, Anita
通讯作者：
Brandstaetter, Anita
影响因子：
64.8
作者：
HARLEY, CB;FUTCHER, AB;GREIDER, CW
通讯作者：
GREIDER, CW