Hyperalgesia and Central Sensitization in Subjects With Chronic Orofacial Pain: Analysis of Pain Thresholds and EEG Biomarkers.
Hyperalgesia and Central Sensitization in Subjects With Chronic Orofacial Pain: Analysis of Pain Thresholds and EEG Biomarkers.
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DOI：
10.3389/fnins.2020.552650
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发表时间：
2020
影响因子：
4.3
通讯作者：
Basaglia N
中科院分区：
文献类型：
--
作者：
Baroni A;Severini G;Straudi S;Buja S;Borsato S;Basaglia N
简介：颞下颌关节紊乱病是引起口面疼痛（OFP）最常见的原因之一。当疼痛持续超过组织愈合时间时，它变成慢性的，并且可能是由高级神经元的敏化引起的。本研究的目的是描述慢性OFP患者的心理特征、外周痛阈和脑电图（EEG）记录，寻找可能的中枢敏感化（CS）迹象。材料与方法：采用颞下颌关节紊乱病研究诊断标准轴I和轴II对24例由颞下颌关节紊乱病引起的慢性OFP患者进行了评价。通过自我报告的问卷调查评估疼痛强度、灾难化和CS的存在。记录面部和外周部位的压痛阈值（PPT）;记录睁眼和闭眼静息状态下以及痛阈值评估期间的EEG活动。疼痛阈值和脑电图记录与一组年龄和性别匹配的无痛健康受试者进行了比较。结果：与健康受试者相比，慢性OFP患者在所有评估部位的痛阈均显著降低。在心理症状更严重的患者中，疼痛阈值的降低幅度更大。在所有受试者的中央和额叶区域记录到α活动减少和γ活动增加，尽管组间没有观察到显著差异。讨论：在患有慢性OFP的人中记录了PPT的普遍减少。这一结果可能是由于慢性疼痛引起的中枢神经系统敏感化所致。在慢性OFP受试者和健康对照者中，与放松条件相比，在疼痛刺激期间记录到异常EEG活动。
Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes chronic and may be caused, among other factors, by the sensitization of higher-order neurons. The aim of this study is to describe psychological characteristics of patients with chronic OFP, their peripheral pain threshold, and electroencephalography (EEG) recording, looking for possible signs of central sensitization (CS). Materials and methods: Twenty-four subjects with chronic OFP caused by temporomandibular disorder were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders Axis I and Axis II. Pain intensity, catastrophizing, and presence of CS were assessed through self-reported questionnaires. Pressure pain threshold (PPT) was recorded in facial and peripheral sites; EEG activity was recorded during open and closed eyes resting state and also during the pain threshold assessment. Pain thresholds and EEG recordings were compared with a cohort of pain-free age- and sex-matched healthy subjects. Results: Patients with chronic OFP showed a significant reduction in their pain threshold compared to healthy subjects in all sites assessed. Greater reduction in pain threshold was recorded in patients with more severe psychological symptoms. Decreased alpha and increased gamma activity was recorded in central and frontal regions of all subjects, although no significant differences were observed between groups. Discussion: A general reduction in PPT was recorded in people who suffer from chronic OFP. This result may be explained by sensitization of the central nervous system due to chronic pain conditions. Abnormal EEG activity was recorded during painful stimulation compared to the relaxed condition in both chronic OFP subjects and healthy controls.
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影响因子：
7.4
作者：
Fillingim, Roger B.;Slade, Gary D.;Ohrbach, Richard
通讯作者：
Ohrbach, Richard
影响因子：
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