Subjective evaluation of experimental dyspnoea--effects of isocapnia and repeated exposure.
Subjective evaluation of experimental dyspnoea--effects of isocapnia and repeated exposure.
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DOI：
10.1016/j.resp.2014.12.019
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发表时间：
2015-03
影响因子：
2.3
通讯作者：
Pattinson, Kyle T. S.
中科院分区：
文献类型：
--
作者：
Hayen, Anja;Herigstad, Mari;Wiech, Katja;Pattinson, Kyle T. S.
功能性神经影像学有望了解呼吸困难的大脑处理。实验性呼吸困难改变了PaCO2，这混淆了FMRI对比度。实验稳定CO2对呼吸负荷的感知影响最小。在四个实验会话中没有出现对电阻性负载的感知习惯。阻力性呼吸负荷是诱导实验性呼吸困难的既定刺激。与无负荷呼吸相比，阻力负荷呼吸改变了潮气末CO2（PETCO2），这具有独立的生理效应（例如，对脑血流）。我们研究了在不同基线水平的轻度高碳酸血症（增加的PETCO2）上手动控制吸入气体期间，稳定PETCO2（等碳酸血症）的阻力负荷呼吸的主观影响。此外，为了调查是否发生对呼吸困难刺激的知觉习惯化，该研究重复了四个实验会话。等碳酸血症不会影响阻力负荷期间的呼吸困难不适。事后分析显示，在+0.6 kPa（可靠诱导等碳酸血症的水平）下无负荷呼吸期间，呼吸不适略有增加。我们没有观察到知觉习惯在四个会议。我们的结论是，等二氧化碳呼吸负荷允许稳定的呼吸不愉快的诱导，使其成为一个很好的刺激多会话研究呼吸困难。
Functional neuroimaging is poised to understand brain processing of dyspnoea. Experimental dyspnoea alters PaCO2, which confounds FMRI contrast. Experimentally stabilizing CO2 had minimal effects on perception of respiratory loads. No perceptual habituation to resistive loads occurred over four experimental sessions. Resistive respiratory loading is an established stimulus for the induction of experimental dyspnoea. In comparison to unloaded breathing, resistive loaded breathing alters end-tidal CO2 (PETCO2), which has independent physiological effects (e.g. upon cerebral blood flow). We investigated the subjective effects of resistive loaded breathing with stabilized PETCO2 (isocapnia) during manual control of inspired gases on varying baseline levels of mild hypercapnia (increased PETCO2). Furthermore, to investigate whether perceptual habituation to dyspnoea stimuli occurs, the study was repeated over four experimental sessions. Isocapnic hypercapnia did not affect dyspnoea unpleasantness during resistive loading. A post hoc analysis revealed a small increase of respiratory unpleasantness during unloaded breathing at +0.6 kPa, the level that reliably induced isocapnia. We did not observe perceptual habituation over the four sessions. We conclude that isocapnic respiratory loading allows stable induction of respiratory unpleasantness, making it a good stimulus for multi-session studies of dyspnoea.
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影响因子：
5.7
作者：
Wise, RG;Ide, K;Tracey, I
通讯作者：
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作者：
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DOI：
10.1097/00004647-200209000-00002
发表时间：
2002-09-01
影响因子：
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影响因子：
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作者：
BlochSalisbury, E;Shea, SA;Banzett, RB
通讯作者：
Banzett, RB