HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients.
HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients.
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HLA 和 KIR 基因分型与慢性粒细胞白血病患者 T 细胞充足单倍体移植后的复发相关
DOI：
10.1038/bjc.2014.423
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发表时间：
2014-09-09
影响因子：
8.8
通讯作者：
Huang, X-J
中科院分区：
文献类型：
--
作者：
Zhao, X-Y;Chang, Y-J;Xu, L-P;Zhang, X-H;Liu, K-Y;Li, D.;Huang, X-J
关于同种异体反应性自然杀伤(NK)细胞对白血病患者移植结果的预测作用，已有相互矛盾的结果报道。我们前瞻性地分析了97例CML患者供受者对的人类白细胞抗原(HLA)分型和供者的KIR分型，以探讨NK细胞在T细胞全相合半相合移植后复发的预测作用。具有供体抑制KIR基因I类配体的患者分子复发率和血液学复发率降低(分别为P=0.003和P=0.015)。与其余移植组(n=72，P=0.009和P=0.009)相比，HLAC1C2或C2C2患者接受KIR2DS1供者或HLABw4患者接受KIR3DS1供者(受者具有相关KIR配体以激活KIR，n=25)的分子和血液学复发风险显著降低。此外，供体激活KIR受体中存在I类配体有助于降低供体抑制KIR受体中缺乏I类配体的患者的复发率(分别为P=0.04和P=0.03)。这项研究表明，供体激活或供体抑制的KIR基因在受者体内的I类配体的存在可能对T细胞全相合半相合移植中的白血病复发具有一定的保护作用。
Conflicting results have been reported regarding the predicative roles of alloreactive natural killer (NK) cells on the outcomes of transplantation in leukaemia patients. We prospectively analysed the human leukocyte antigen (HLA) typing of donor–recipient pairs and the KIR typing of the donors in 97 CML patients to address the predictive roles of NK cells in relapse undergoing T-cell-replete haploidentical transplantation. Patients with class I ligands for the donor-inhibitory KIR gene exhibited decreased molecular and haematologic relapse rates (P=0.003 and P=0.015, respectively). There was a significantly reduced risk of molecular and haematologic relapse in patients with HLA-C1C2 or C2C2 who accepted donors with KIR2DS1 or in patients with HLA-Bw4 who accepted donors with KIR3DS1 (‘recipient with relevant KIR ligand for donor-activating KIR', n=25), compared with the remaining transplants (n=72, P=0.009 and P=0.009, respectively). In addition, the presence of class I ligand in the recipients of donor-activating KIR contributed to a decreased relapse rate in patients lacking class I ligand in the recipient of donor-inhibitory KIR (P=0.04 and P=0.03, respectively). This study suggests that the presence of class I ligands for the donor-activating or donor-inhibitory KIR gene in the recipient might confer some protection against leukaemic relapse in T-cell-replete haploidentical transplantation.
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影响因子：
64.8
作者：
Sun, Joseph C.;Beilke, Joshua N.;Lanier, Lewis L.
通讯作者：
Lanier, Lewis L.
影响因子：
20.3
作者：
Vago, Luca;Forno, Barbara;Fleischhauer, Katharina
通讯作者：
Fleischhauer, Katharina
影响因子：
20.3
作者：
Yawata, Makoto;Yawata, Nobuyo;Parham, Peter
通讯作者：
Parham, Peter
影响因子：
20.3
作者：
Ruggeri, Loredana;Mancusi, Antonella;Velardi, Andrea
通讯作者：
Velardi, Andrea
影响因子：
20.3
作者：
Sungur, Can M.;Tang-Feldman, Yajarayma J.;Murphy, William J.
通讯作者：
Murphy, William J.