Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease.
Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease.
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DOI：
10.1007/s12013-014-0006-5
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发表时间：
2014-11
影响因子：
2.6
通讯作者：
Tyagi N
中科院分区：
文献类型：
--
作者：
Kamat PK;Kalani A;Kyles P;Tyagi SC;Tyagi N
The autophagic process is the only known mechanism for mitochondrial turnover and it has been speculated that dysfunction of autophagy may result in mitochondrial error and cellular stress. Emerging investigations have provided new understanding of how autophagy of mitochondria (also known as mitophagy) is associated with cellular oxidative stress and its impact on neuro-degeneration. This impaired autophagic function may be considered as a possible mechanism in the pathogenesis of several neurodegenerative disorders including: Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington disease (HD). It can be suggested that autophagy dysfunction along with oxidative stress are considered main events in neurodegenerative disorders. New therapeutic approaches have now begun to target mitochondria as a potential drug target. This review discusses evidence supporting the notion that oxidative stress and autophagy are intimately associated with neurodegenerative disease pathogenesis. This review also explores new approaches that can prevent mitochondrial dysfunction, improve neurodegenerative etiology, and also offer possible cures to the aforementioned neurodegenerative diseases.
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通讯作者：
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