Telomere regulation in pluripotent stem cells.
Telomere regulation in pluripotent stem cells.
复制标题
多能干细胞的端粒调控
DOI：
10.1007/s13238-014-0028-1
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发表时间：
2014-03
期刊：
影响因子：
21.1
通讯作者：
Songyang, Zhou
中科院分区：
文献类型：
--
作者：
Huang, Yan;Liang, Puping;Liu, Dan;Huang, Junjiu;Songyang, Zhou
多能干细胞（PSC）具有从所有三个基本胚层产生任何类型细胞的潜力，并且具有自我更新和在体外无限增殖的能力。PSC的两种主要类型，胚胎干细胞（ESC）和诱导多能干细胞（iPSC），具有共同的特征，如集落形态，Oct4和Nanog的高表达，以及强碱性磷酸酶活性。近年来，越来越多的证据表明端粒长度是维持干细胞多能性的另一个重要内在因素。端粒长度的稳态及其结构的完整性有助于保护染色体末端免于重组、末端融合和DNA损伤反应，从而确保哺乳动物细胞的分裂能力。PSC通常表现出较高的端粒酶活性，以维持其极长且稳定的端粒，新出现的数据表明端粒替代延长（ALT）途径也可能在端粒功能中发挥重要作用。这些特征可能是它们在体内分化成不同细胞类型的能力的关键。在这篇综述中，我们将重点介绍端粒在胚胎干细胞和诱导多能干细胞中的功能和调控，从而阐明端粒长度对多能性的重要性以及调节端粒在诱导多能干细胞中的机制。
Pluripotent stem cells (PSCs) have the potential to produce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), share common features such as colony morphology, high expression of Oct4 and Nanog, and strong alkaline phosphatase activity. In recent years, increasing evidences suggest that telomere length represents another important internal factor in maintaining stem cell pluripotency. Telomere length homeostasis and its structural integrity help to protect chromosome ends from recombination, end fusion, and DNA damage responses, ensuring the divisional ability of mammalian cells. PSCs generally exhibit high telomerase activity to maintain their extremely long and stable telomeres, and emerging data indicate the alternative lengthening of telomeres (ALT) pathway may play an important role in telomere functions too. Such characteristics are likely key to their abilities to differentiate into diverse cell types in vivo. In this review, we will focus on the function and regulation of telomeres in ESCs and iPSCs, thereby shedding light on the importance of telomere length to pluripotency and the mechanisms that regulate telomeres in PSCs.
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影响因子：
10.5
作者：
Drane, Pascal;Ouararhni, Khalid;Hamiche, Ali
通讯作者：
Hamiche, Ali
影响因子：
64.8
作者：
Batista, Luis F. Z.;Pech, MatthewF.;Zhong, Franklin L.;Nguyen, Ha Nam;Xie, Kathleen T.;Zaug, Arthur J.;Crary, Sharon M.;Choi, Jinkuk;Sebastiano, Vittorio;Cherry, Athena;Giri, Neelam;Wernig, Marius;Alter, Blanche P.;Cech, Thomas R.;Savage, Sharon A.;Pera, Renee A. Reijo;Artandi, Steven E.
通讯作者：
Artandi, Steven E.
影响因子：
16
作者：
Chen, Liuh-Yow;Zhang, Yi;Zhang, Qinfen;Li, Hongzhi;Luo, Zhenhua;Fang, Hezhi;Kim, Sok Ho;Qin, Li;Yotnda, Patricia;Xu, Jianming;Tu, Benjamin P.;Bai, Yidong;Zhou Songyang
通讯作者：
Zhou Songyang
影响因子：
5.2
作者：
Armstrong, L;Saretzki, G;Lako, M
通讯作者：
Lako, M
DOI：
10.4161/nucl.20326
发表时间：
2012-05
期刊：
Nucleus (Austin, Tex.)
影响因子：
--
作者：
Chung I;Osterwald S;Deeg KI;Rippe K
通讯作者：
Rippe K