NKT‐associated markers and perforin in hyperplastic thymuses from patients with Myasthenia gravis
NKT‐associated markers and perforin in hyperplastic thymuses from patients with Myasthenia gravis
复制标题
重症肌无力患者增生性胸腺中的 NKT 相关标记物和穿孔素
作者：
Y. Nagane;K. Utsugisawa;D. Obara;H. Tohgi
在重症肌无力 (MG) 患者的增生性胸腺中研究了自然杀伤 T (NKT) 细胞相关标记物（Vα24 和 CD56）和穿孔素与 CD44 高阳性 (CD44high) 细胞相关的免疫组织化学表达，与非 MG 对照胸腺相比，重症肌无力 (MG) 患者的症状在胸腺切除后显着改善。在对照胸腺中，Vα24 阳性（Vα24+）和 CD56 阳性（CD56+）细胞仅稀疏分布在髓质区域。相反，在增生性 MG 胸腺中，Vα24+ 和 CD56+ 细胞在结缔组织中更为常见，似乎已穿透胸腺实质，并且大多数共表达 CD44high。穿孔素阳性细胞不存在于对照胸腺中，但存在于增生性 MG 胸腺的结缔组织和小叶周围皮质区域中。大多数穿孔素阳性细胞 CD44 高且位于血管附近。它们似乎直接从血管系统迁移并穿透胸腺实质。一些穿孔素阳性细胞共表达 Vα24、CD56 或两者。这些发现表明，在这种特殊类型的 MG 胸腺中，NKT 样细胞可能通过 CD44 和穿孔素介导的机制增加，导致免疫系统失衡，有利于抗体介导的针对乙酰胆碱受体的自身免疫。 © 2001 John Wiley & Sons, Inc. 肌肉神经 24：1359–1364，2001
Immunohistochemical expression of natural killer T (NKT) cell–associated markers (Vα24 and CD56) and perforin in relation to CD44–highly positive (CD44high) cells was studied in hyperplastic thymuses from patients with myasthenia gravis (MG) whose symptoms dramatically improved after thymectomy and compared with non‐MG control thymuses. In the control thymuses, Vα24‐positive (Vα24+) and CD56‐positive (CD56+) cells were sparsely distributed in the medullary area only. In contrast, in hyperplastic MG thymus, Vα24+ and CD56+ cells were more frequent in connective tissue, appeared to have penetrated the thymic parenchyma, and most coexpressed CD44high. Perforin‐positive cells were not present in the control thymus, but were in the connective tissue and perilobular cortical areas in the hyperplastic MG thymus. Most of these perforin‐positive cells were CD44high and were located near blood vessels. They appeared to have migrated directly from the vascular system and penetrated the thymic parenchyma. Some perforin‐positive cells coexpressed Vα24, CD56, or both. These findings suggest that in this particular type of MG thymus, NKT‐like cells may have increased via a CD44‐ and perforin‐mediated mechanism, leading to an imbalance in the immune system that favored an antibody‐mediated autoimmunity against the acetylcholine receptor. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1359–1364, 2001
CD44 激活和相关的初级粘附是通过 T 细胞受体刺激诱导的。
DOI：
--
发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
DeGrendele,HC;Kosfiszer,M;Estess,P;Siegelman,MH
通讯作者：
Siegelman,MH
实验性自身免疫性重症肌无力中辅助 T 细胞克隆对抗体产生的调节。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fujii,Y;Lindstrom,J
通讯作者：
Lindstrom,J
DOI：
10.1073/pnas.89.14.6506
发表时间：
1992-07-15
影响因子：
11.1
作者：
ARASE, H;ARASE, N;ONOE, K
通讯作者：
ONOE, K