The interplay of electrode- and bio-materials in a redox-cycling-based clozapine sensor.
The interplay of electrode- and bio-materials in a redox-cycling-based clozapine sensor.
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DOI：
10.1016/j.elecom.2017.04.009
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发表时间：
2017-06
影响因子：
5.4
通讯作者：
Ghodssi R
中科院分区：
文献类型：
--
作者：
Winkler TE;Dietrich R;Kim E;Ben-Yoav H;Kelly DL;Payne GF;Ghodssi R
我们研究了金、氮化钛和铂与基于壳聚糖 - 儿茶酚的氧化还原循环系统（RCS）相结合，用于抗精神病药物氯氮平的电化学检测。我们之前已经展示了用于检测血清中氯氮平的RCS，但在低信噪比方面仍然存在挑战。这可以通过选择具有有利表面形态和/或成分的电极材料来缓解。我们采用循环伏安法来评估氯氮平产生的氧化还原电流，并使用标准氧化还原对将单纯基于表面积的效应与氯氮平特异性效应区分开来。我们发现，与金相比，纳米和微结构的铂极大地放大了氯氮平信号（对于铂黑，高达1490倍）。然而，该材料在氯离子存在的情况下表现不佳，并且RCS修饰没有进一步放大信号。另一方面，RCS与原子层沉积（ALD）氮化钛相结合，使信号增加了7.54倍，而金上的RCS仅增加2.86倍，且变异性低9.2倍，这表明ALD - 氮化钛的均匀和化学惰性特性可能使其成为一种理想的电极材料。
We investigate gold, TiN, and platinum in combination with a chitosan–catechol-based redox-cycling system (RCS) for electrochemical detection of the antipsychotic clozapine. We have previously demonstrated the RCS for detection of clozapine in serum, but challenges remain regarding low signal-to-noise ratios. This can be mitigated by selection of electrode materials with beneficial surface morphologies and/or compositions. We employ cyclic voltammetry to assess the redox current generated by clozapine, and differentiate solely surface-area-based effects from clozapine-specific ones using a standard redox couple. We find that nano- and microstructured platinum greatly amplifies the clozapine signal compared to gold (up to 1490-fold for platinum black). However, the material performs poorly in the presence of chloride ions, and RCS modification provides no further amplification. The RCS combined with atomic-layer-deposited (ALD) TiN, on the other hand, increases the signal by 7.54 times, versus 2.86 times for RCS on gold, with a 9.2-fold lower variability, indicating that the homogenous and chemically inert properties of ALD-TiN may make it an ideal electrode material.
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影响因子：
2.2
作者：
Burke, LD;Nugent, PF
通讯作者：
Nugent, PF
影响因子：
6.6
作者：
Avasarala, Bharat;Haldar, Pradeep
通讯作者：
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影响因子：
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作者：
Kimmel, Danielle W.;LeBlanc, Gabriel;Meschievitz, Mika E.;Cliffel, David E.
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Cliffel, David E.
影响因子：
19
作者：
Kim, Eunkyoung;Liu, Yi;Payne, Gregory F.
通讯作者：
Payne, Gregory F.
影响因子：
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作者：
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通讯作者：
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