Genomic screening of the general adult population: key concepts for assessing net benefit with systematic evidence reviews.

Genomic screening of the general adult population: key concepts for assessing net benefit with systematic evidence reviews.
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DOI:
10.1038/gim.2014.129
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发表时间:
2015-06
期刊:
Genetics in medicine : official journal of the American College of Medical Genetics
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评论是否整体证据提示净危害或利益;或者他们可以利用决策模型来补充SER期间发现的证据。公共卫生基因组筛查的SER可能会突出显着的证据差距,该过程对于告知未来的研究议程非常重要。为了指导SER的文献选择,评审者必须考虑概念模型的以下组成部分。
COMMENTARY whether overall evidence tips toward net harm or benefit; alternatively they can utilize decision modeling to supplement the evidence found during a SER. A SER for public health genomic screening will likely highlight significant evidentiary gaps, and the process is important to inform the future research agenda. To guide literature selection for a SER, reviewers must consider the following components of a conceptual model.
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